ReviewVirus genes2002
Herpes simplex virus evolved to use the human defense mechanisms to establish a lifelong infection in neurons--a review and hypothesis.
Review in Virus genes, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Herpes simplex encephalitis in a patient abusing morphine: a case report from Nepal.Annals of medicine and surgery (2012) · 2023Article
- Crosstalk Between Epithelial Cells, Neurons and Immune Mediators in HSV-1 Skin Infection.Frontiers in immunology · 2021Review
- Using data from 'visible' populations to estimate the size and importance of 'hidden' populations in an epidemic: A modelling technique.Infectious Disease Modelling · 2020Article
- Herpes Simplex Virus Type-1 Infection: Associations with Inflammation and Cognitive Aging in Relation to Schizophrenia.Current topics in behavioral neurosciences · 2020Review
- What Goes Around, Comes Around - HSV-1 Replication in Monocyte-Derived Dendritic Cells.Frontiers in microbiology · 2017Review
- Tryptophan Catabolism in Chronic Viral Infections: Handling Uninvited Guests.International journal of tryptophan research : IJTR · 2015Review
- Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons.Glia · 2011Article
- Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections.Journal of virology · 2004Article
- Immunological and regulatory functions of uninfected and virus infected immature and mature subtypes of dendritic cells--a review.Virus genes · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The review of recent studies using DNA microarrays shed new light on herpes simplex virus (HSV) replicative cycle, the response of immature dendritic cells (DCs) to pathogens and the response of neurons in trigeminal ganglia to virus reactivation. These studies provided a better understanding of the molecular biology of HSV during infection, latency and reactivation. The research on the sensory trigeminal neurons and the neuronal axons (type C fibers) that transverse the skin basal membrane, enter the skin epidermis and interact with the cell membrane of the skin resident immature DCs provided an insight on the connection between the nervous system and the host immune system. Based on these studies a hypothesis is presented suggesting that HSV evolved to use the human host defense systems (pain signals, the immune system cells and sensory neurons) to ensure its entry from the skin epithelium into the sensory neurons. Reactivated HSV in the neurons utilizes the same host defense systems to return to the skin epithelium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.