ArticleVirus genes2002
Species-specific differences in organization of orthopoxvirus kelch-like proteins.
Article in Virus genes, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Patterns of genomic deletions in monkeypox virus during the 2022 outbreak in the United States.Nature communications · 2025Article
- AI-driven drug repurposing and binding pose meta dynamics identifies novel targets for monkeypox virus.Journal of infection and public health · 2023Article
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- Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily.Viruses · 2015Review
- Identification of 10 cowpox virus proteins that are necessary for induction of hemorrhagic lesions (red pocks) on chorioallantoic membranes.Journal of virology · 2014Article
- Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling.Journal of virology · 2014Article
- Orthopoxvirus genes that mediate disease virulence and host tropism.Advances in virology · 2012Article
- Review
- Article
- Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases.Virology · 2008Article
- Sheeppox virus kelch-like gene SPPV-019 affects virus virulence.Journal of virology · 2007Article
- Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response.The Journal of general virology · 2007Article
- Genome of horsepox virus.Journal of virology · 2006Article
- Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association.The Biochemical journal · 2004Article
- Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals.BMC bioinformatics · 2003Article
- 40 Years without Smallpox.Acta naturaeArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organization of orthopoxvirus proteins of the kelch superfamily and their genes were analyzed and compared. Complete genomic sequences of variola (VAR), monkeypox (MPV), vaccinia (VAC), and species-specific regions of cowpox (CPV) viruses were used in the work. Despite the multiplicity of kelch-like proteins in orthopoxviruses, their function is still vague. It has been discovered that the genes of orthopoxvirus kelch-like proteins are localized only to the terminal variable regions of the genome and display species-specific differences in the lengths of the proteins they potentially encode. All the genes belonging to kelch superfamily in the genome of VAR, which has the only host-the man, are mutationally destroyed. However, CPV, displaying the widest host range among orthopoxviruses, encode the most numerous set of kelch-like proteins. Weak homologies between kelch-like proteins of one virus were demonstrated as well as high homologies between isologues of different orthopoxvirus species. The comparison performed suggest that CPV virus is most ancient and may be considered as the ancestor of other orthopoxviruses pathogenic for humans.
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