ReviewImmunologic research2002
Regulation of chemokine expression by antiinflammatory cytokines.
Review in Immunologic research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 87 citations in OpenAlex.
- Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints.Journal of advanced research · 2026Review
- Chemokines in Cartilage Regeneration and Degradation: New Insights.International journal of molecular sciences · 2023Review
- Discovery of a pyrano[2,3-b]pyridine derivative YX-2102 as a cannabinoid receptor 2 agonist for alleviating lung fibrosis.Journal of translational medicine · 2022Article
- Receptor-selective interleukin-4 mutein attenuates laser-induced choroidal neovascularization through the regulation of macrophage polarization in mice.Experimental and therapeutic medicine · 2021Article
- Article
- The Orally Active Noncompetitive AMPAR Antagonist Perampanel Attenuates Focal Cerebral Ischemia Injury in Rats.Cellular and molecular neurobiology · 2018Article
- Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome.Mediators of inflammation · 2018Article
- Translational Nano-Medicines: Targeted Therapeutic Delivery for Cancer and Inflammatory Diseases.The AAPS journal · 2015Review
- Macrophage activation and skeletal muscle healing following traumatic injury.The Journal of pathology · 2014Article
- Regulation of chemokine expression in the tumor microenvironment.Critical reviews in immunology · 2014Review
- Article
- Diversity in sequence-dependent control of GRO chemokine mRNA half-life.Journal of leukocyte biology · 2013Article
- Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection.The Indian journal of medical research · 2012Article
- Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases.Toxins · 2012Review
- MAPK usage in periodontal disease progression.Journal of signal transduction · 2012Article
- Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism.Neurobiology of disease · 2011Article
- Effects of protein-energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages.Inflammation · 2010Article
- Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Poly (lactide-co-glycolide)-polymethacrylate nanoparticles for intramuscular delivery of plasmid encoding interleukin-10 to prevent autoimmune diabetes in mice.Pharmaceutical research · 2009Article
- Suppression of lipopolysaccharide-stimulated tumor necrosis factor-alpha production by adiponectin is mediated by transcriptional and post-transcriptional mechanisms.The Journal of biological chemistry · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The antiinflammatory cytokines IL-4 and IL- 10 are well recognized as important negative regulators of proinflammatory gene expression in mononuclear phagocytes. The intracellular mechanisms that mediate these responses appear to be multifactorial. IL-4 is able to suppress transcriptional activation of IFNgamma- and LPS-responsive genes; IL-4 activated STAT6 is required for the suppressive activity of IL-4. IL-4 and STAT6 appear to suppress transcription of select proinflammatory genes through the ability of STAT6 to sequester coactivator molecules that may be required for the transcriptional action of STAT1 and NFkappaB. In contrast, IL-10 suppresses the expression of genes induced in lipopolysaccharide (LPS)-stimulated macrophages by modulating both the transcription and stability of specific mRNAs. AU-rich nucleotide sequence elements in the 3'untranslated region of IL-10-sensitive genes confer sensitivity to IL-10-mediated destabilization. Thus mechanisms through which IL-10 and IL-4 act to dampen inflammatory responses are mechanistically distinct and involve diverse intracellular signaling pathways.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.