Trial reportAnnals of medicine2002
Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima-media thickness measurement.
Trial report in Annals of medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01683656 (ER Niacin/Laropiprant Impact on Cardiovascular Markers and Atheroprogression in HIV-infected Individuals on cART), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ER Niacin/Laropiprant Impact on Cardiovascular Markers and Atheroprogression in HIV-infected Individuals on cART
Who cites it
26 citing papers in PubMed, 126 citations in OpenAlex.
- Prevention of atherosclerosis in patients living with HIV.Vascular health and risk management · 2009Trial
- Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1.PLoS medicine · 2004Trial
- Homocysteine modifies the association of coronary stenosis and HIV infection in an inner city African American population.International journal of STD & AIDS · 2024Article
- Direct and indirect cardiovascular and cardiometabolic sequelae of the combined anti-retroviral therapy on people living with HIV.Frontiers in physiology · 2023Review
- Prevalence and risk factors of high cholesterol and triglycerides among people with HIV in Texas.AIDS research and therapy · 2022Article
- HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women.JACC. Basic to translational science · 2022Review
- Association Between the Framingham Risk Score and Carotid Artery Intima-Media Thickness in Patients With Human Immunodeficiency Virus.The American journal of cardiology · 2020Article
- The Opioid Epidemic: Impact on Inflammation and Cardiovascular Disease Risk in HIV.Current HIV/AIDS reports · 2019Review
- Visceral adipose tissue and carotid intima-media thickness in HIV-infected patients undergoing cART: a prospective cohort study.BMC infectious diseases · 2018Article
- The Impact of Weight Gain During HIV Treatment on Risk of Pre-diabetes, Diabetes Mellitus, Cardiovascular Disease, and Mortality.Frontiers in endocrinology · 2018Review
- Atherosclerosis is Evident in Treated HIV-Infected Subjects With Low Cardiovascular Risk by Carotid Cardiovascular Magnetic Resonance.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Elevated homocysteine levels in human immunodeficiency virus-infected patients under antiretroviral therapy: A meta-analysis.World journal of virology · 2015Article
- Carotid intima media thickness is associated with body fat abnormalities in HIV-infected patients.BMC infectious diseases · 2014Article
- Lipoprotein-associated phospholipase A2, a novel cardiovascular inflammatory marker, in HIV-infected patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
- Risk factors for subclinical atherosclerosis in HIV-infected patients under and over 40 years: a case-control study.BMC infectious diseases · 2013Article
- Effects of aging and smoking on carotid intima-media thickness in HIV-infection.AIDS (London, England) · 2013Article
- Impaired distensibility of ascending aorta in patients with HIV infection.BMC infectious diseases · 2012Article
- Hypertriglyceridemia, Metabolic Syndrome, and Cardiovascular Disease in HIV-Infected Patients: Effects of Antiretroviral Therapy and Adipose Tissue Distribution.International journal of vascular medicine · 2012Article
- A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults.AIDS research and human retroviruses · 2011Article
- Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D study(*).HIV medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHighly active antiretroviral therapies (HAART) in HIV-infected patients are often associated with lipodystrophy syndrome and metabolic disorders. Atherogenic lipid profile could expose these patients to atheromatous cardiovascular disease. We describe carotid artery intima-media thickness (IMT), a surrogate marker of atherosclerosis, according to HIV status, antiretroviral treatment, lipodystrophy and conventional cardiovascular risk factors.
methodIn a multicenter prospective cohort study we have surveyed HIV-infected subjects with a carotid IMT measurement by B-mode ultrasonography. We collected information on lipodystrophy clinical manifestations, age, gender, body mass index (BMI), smoking habits, alcohol intake, systolic blood pressure, HIV transmission category, AIDS stage, type and duration of HAART, CD4+ cell count, plasma HIV-1 RNA, glucose, insulin, total cholesterol and homocysteine.
resultsFour hundred and twenty-three HIV-infected patients were studied. The median carotid IMT measurement was 0.54 mm (range: 0.50-0.60). Lipodystrophy syndrome was diagnosed in 161 HIV-infected patients (38.1%). In univariate linear regression, IMT was significantly higher (P<0.05) with older age, male gender, higher body mass index, higher waist-to-hip ratio, increased systolic blood pressure, total cholesterol, glucose disorders and homocysteine, regular smoking and alcohol consumption, lipodystrophy and HAART. In a multivariate analysis, the effect of lipodystrophy and HAART disappeared after adjustment for other cardiovascular risk factors.
conclusionsIt was concluded that only conventional cardiovascular risk factors are independently associated with increased IMT in HIV-infected patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.