ArticleProceedings of the National Academy of Sciences of the United States of America2002
MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 122 citations in OpenAlex.
- Does Bisphenol A (BPA) Exposure Cause Human Diseases?Biomedicines · 2024Review
- Drug Transporters at the Human Blood-Testis Barrier.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier.Journal of xenobiotics · 2023Review
- The long non-coding RNAAnnals of translational medicine · 2022Article
- MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Joint Lp-Norm and LFrontiers in genetics · 2021Article
- Article
- Dysfunction of Oskyddad causes Harlequin-type ichthyosis-like defects in Drosophila melanogaster.PLoS genetics · 2020Article
- Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer.Medicine · 2019Article
- Glucuronidation: driving factors and their impact on glucuronide disposition.Drug metabolism reviews · 2017Review
- Multidrug Resistance Proteins (MRPs) and Cancer Therapy.The AAPS journal · 2015Review
- Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries.Nature protocols · 2013Article
- Multidrug resistance associated proteins in multidrug resistance.Chinese journal of cancer · 2012Review
- Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.The FEBS journal · 2011Review
- Drug transporters, the blood-testis barrier, and spermatogenesis.The Journal of endocrinology · 2011Review
- Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei.Malaria journal · 2009Article
- Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies.European journal of immunology · 2008Article
- Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.The Biochemical journal · 2007Article
- ABCC10, ABCC11, and ABCC12.Pflugers Archiv : European journal of physiology · 2007Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combining a computer-based screening strategy and functional genomics, we previously identified MRP9 (ABCC12), a member of the ATP-binding cassette (ABC) superfamily. We now show that the gene has two major transcripts of 4.5 and 1.3 kb. In breast cancer, normal breast, and testis, the MRP9 gene transcript is 4.5 kb in size and encodes a 100-kDa protein. The protein is predicted to have 8 instead of 12 membrane-spanning regions. When compared with closely related ABC family members, it lacks transmembrane domains 3, 4, 11, and 12 and the second nucleotide-binding domain. In other tissues including brain, skeletal muscle, and ovary, the transcript size is 1.3 kb. This smaller transcript encodes a nucleotide-binding protein of approximately 25 kDa in size. An in situ hybridization study shows that the 4.5-kb transcript is expressed in the epithelial cells of breast cancer. An antipeptide antibody designed to react with the amino terminus of the protein detects a 100-kDa protein in testis and the membrane fraction of a breast cancer cell line. Because the 4.5-kb RNA is highly expressed in breast cancer and not expressed at detectable levels in essential normal tissues, MRP9 could be a useful target for the immunotherapy of breast cancer. Because of the unusual topology of the two variants of MRP9, we speculate that they may have a different function from other family members.
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