ArticleProceedings of the National Academy of Sciences of the United States of America2002
A flagellar K(+)-dependent Na(+)/Ca(2+) exchanger keeps Ca(2+) low in sea urchin spermatozoa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 89 citations in OpenAlex.
- The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-CaToxics · 2024Article
- Hamster Sperm Possess Functional NaInternational journal of molecular sciences · 2023Article
- Structure and Function of Ion Channels Regulating Sperm Motility-An Overview.International journal of molecular sciences · 2021Review
- Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation.The EMBO journal · 2020Article
- The steering gaits of sperm.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Transcriptional profiling and physiological roles of Aedes aegypti spermathecal-related genes.BMC genomics · 2020Article
- Only a subpopulation of mouse sperm displays a rapid increase in intracellular calcium during capacitation.Journal of cellular physiology · 2018Article
- Molecular Basis of Human Sperm Capacitation.Frontiers in cell and developmental biology · 2018Review
- Sperm Sensory Signaling.Cold Spring Harbor perspectives in biology · 2017Review
- Network model predicts that CatSper is the main CaScientific reports · 2017Article
- Transcriptome and biomineralization responses of the pearl oyster Pinctada fucata to elevated CO2 and temperature.Scientific reports · 2016Article
- Soluble adenylyl cyclase of sea urchin spermatozoa.Biochimica et biophysica acta · 2014Review
- 100 years of sperm chemotaxis.The Journal of general physiology · 2012Article
- Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm.The Journal of cell biology · 2012Article
- What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?Biophysical journal · 2012Article
- Discrete dynamics model for the speract-activated Ca2+ signaling network relevant to sperm motility.PloS one · 2011Article
- Impact of marine drugs on cytoskeleton-mediated reproductive events.Marine drugs · 2010Review
- The influence of bioactive oxylipins from marine diatoms on invertebrate reproduction and development.Marine drugs · 2009Review
- Ca2+ spikes in the flagellum control chemotactic behavior of sperm.The EMBO journal · 2005Article
- The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond.Pflugers Archiv : European journal of physiology · 2004Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The metabolism, flagellar beating, and acrosome reaction of spermatozoa are regulated by ion flux across the plasma membrane. As is true of most cells, swimming sperm maintain intracellular Ca(2+) concentrations at submicromolar levels. Here we describe a K(+)-dependent Na(+)/Ca(2+) exchanger (suNCKX) from sea urchin sperm. The suNCKX is phylogenetically related to other NCKXs, which use high relative intracellular K(+), and high relative extracellular Na(+), to couple the efflux of 1 Ca(2+) and 1 K(+) to the influx of 4 Na(+). The 652-aa suNCKX shares structural topology with other NCKX proteins, and has two protein kinase A sites and a His-rich region in its cytoplasmic loop. The suNCKX is encoded by a single gene, which is highly expressed in testes. The suNCKX activity of whole sperm shows Na(+) and K(+) dependence, and like other NCKXs can run in reverse exchange mode. An inhibitor blocks the suNCKX activity and sperm motility. suNCKX localizes to the plasma membrane over the sperm flagellum. The suNCKX may play a major role in keeping Ca(2+) low in swimming sperm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.