ArticleProceedings of the National Academy of Sciences of the United States of America2002
Bidirectional cooperative motion of molecular motors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 188 citations in OpenAlex.
- Long-term memory induced correction to Arrhenius law.Nature communications · 2024Article
- Entropy by Neighbor Distance as a New Measure for Characterizing Spatiotemporal Orders in Microscopic Collective Systems.Micromachines · 2023Article
- Microscopic Swarms: From Active Matter Physics to Biomedical and Environmental Applications.Micromachines · 2022Review
- Large and reversible myosin-dependent forces in rigidity sensing.Nature physics · 2019Article
- Order-disorder transition in active nematic: A lattice model study.Scientific reports · 2017Article
- Coordinated force generation of skeletal myosins in myofilaments through motor coupling.Nature communications · 2017Article
- Embedding dual function into molecular motors through collective motion.Scientific reports · 2017Article
- Metaphase Spindle Assembly.Biology · 2017Review
- Impact of correlated noise in an energy depot model.Scientific reports · 2016Article
- Ribosomal trafficking is reduced in Schwann cells following induction of myelination.Frontiers in cellular neuroscience · 2015Article
- Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function.Biophysical journal · 2014Article
- Multimotor transport in a system of active and inactive kinesin-1 motors.Biophysical journal · 2014Article
- The kinetics of mechanically coupled myosins exhibit group size-dependent regimes.Biophysical journal · 2013Article
- Bifurcation of velocity distributions in cooperative transport of filaments by fast and slow motors.Biophysical journal · 2013Article
- A stochastic model of kinetochore-microtubule attachment accurately describes fission yeast chromosome segregation.The Journal of cell biology · 2012Article
- Hybrid four-headed myosin motor engineered with antagonistic motor domains.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Dynamical behavior of molecular motor assemblies in the rigid and crossbridge models.The European physical journal. E, Soft matter · 2011Article
- A computational model predicts Xenopus meiotic spindle organization.The Journal of cell biology · 2010Article
- Real-time monitoring of cell elasticity reveals oscillating myosin activity.Biophysical journal · 2010Article
- Bidirectional transport by molecular motors: enhanced processivity and response to external forces.Biophysical journal · 2010Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, in a beautiful set of experiments, it has been shown that a Ncd mutant, NK11, which lacks directionality in its individual motion, was able to exhibit a new kind of directed motion in motility assays (Endow, S. A. & Higuchi, H. (2000) Nature (London) 406, 913-916): the filaments keep a given velocity for a while and then suddenly move in the opposite direction with similar velocity. We show that these observations nicely illustrate the concept of dynamic transitions in motor collections introduced earlier in the case of an infinite number of motors. We investigate the experimentally relevant case of a finite number of motors both when directionality is present (kinesins, myosins, Ncd) and absent (NK11). Using a symmetric two-state model, we demonstrate that bidirectional motion is the signature of a dynamic transition that results from the collective behavior of many motors acting on the same filament. For motors exhibiting directional bias individually, an asymmetric two-state model is appropriate. In that case, dynamic transitions exist for motor collections in the presence of an external force. We give predictions for the dependence of motion on ATP concentration, external forces, and the number of motors involved. In particular, we show that the reversal time grows exponentially with the number of motors per filament.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.