ArticleThe Journal of cell biology2002
Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Engineered human myogenic cells in hydrogels generate innervated vascularized myofibers within dystrophic mouse muscle on long-term engraftment.Cell reports. Medicine · 2025Article
- Transplantation to study satellite cell heterogeneity in skeletal muscle.Frontiers in cell and developmental biology · 2022Review
- Local Preirradiation of Infarcted Cardiac Tissue Substantially Enhances Cell Engraftment.International journal of molecular sciences · 2021Article
- Skeletal muscle cell transplantation: models and methods.Journal of muscle research and cell motility · 2020Article
- Irradiation dependent inflammatory response may enhance satellite cell engraftment.Scientific reports · 2020Article
- Full-length Dysferlin Transfer by the Hyperactive Sleeping Beauty Transposase Restores Dysferlin-deficient Muscle.Molecular therapy. Nucleic acids · 2016Article
- The effect of environmental chemicals on the tumor microenvironment.Carcinogenesis · 2015Review
- Satellite cells from dystrophic muscle retain regenerative capacity.Stem cell research · 2015Article
- A differential response to newt regeneration extract by C2C12 and primary mammalian muscle cells.Skeletal muscle · 2015Article
- The effect of the muscle environment on the regenerative capacity of human skeletal muscle stem cells.Skeletal muscle · 2015Article
- Human skeletal muscle-derived CD133(+) cells form functional satellite cells after intramuscular transplantation in immunodeficient host mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy.Seminars in radiation oncology · 2013Review
- The evolution of the cancer niche during multistage carcinogenesis.Nature reviews. Cancer · 2013Review
- Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice.Journal of radiation research · 2013Article
- New biological insights on the link between radiation exposure and breast cancer risk.Journal of mammary gland biology and neoplasia · 2013Review
- Molecular pathways: involving microenvironment damage responses in cancer therapy resistance.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- The satellite cell in male and female, developing and adult mouse muscle: distinct stem cells for growth and regeneration.PloS one · 2012Article
- Article
- Stromal mediation of radiation carcinogenesis.Journal of mammary gland biology and neoplasia · 2010Review
- Are human and mouse satellite cells really the same?The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental influences have profound yet reversible effects on the behavior of resident cells. Earlier data have indicated that the amount of muscle formed from implanted myogenic cells is greatly augmented by prior irradiation (18 Gy) of the host mouse muscle. Here we confirm this phenomenon, showing that it varies between host mouse strains. However, it is unclear whether it is due to secretion of proliferative factors or reduction of antiproliferative agents. To investigate this further, we have exploited the observation that the immortal myogenic C2 C12 cell line forms tumors far more rapidly in irradiated than in nonirradiated host muscle. We show that the effect of preirradiation on tumor formation is persistent and dose dependent. However, C2 C12 cells are not irreversibly compelled to form undifferentiated tumor cells by the irradiated muscle environment and are still capable of forming large amounts of muscle when reimplanted into a nonirradiated muscle. In a clonal analysis of this effect, we discovered that C2 C12 cells have a bimodal propensity to form tumors; some clones form no tumors even after extensive periods in irradiated graft sites, whereas others rapidly form extensive tumors. This illustrates the subtle interplay between the phenotype of implanted cells and the factors in the muscle environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.