ArticleThe Journal of cell biology2002
Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 112 citations in OpenAlex.
- MOS is a key regulator of meiotic midbody assembly and prevents abnormal divisions in mouse eggs and their polar bodies.Journal of cell science · 2026Article
- Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions.The Journal of cell biology · 2025Article
- MAPK1IP1L::TFE3-rearranged renal cell carcinoma: a novel fusion adding to the differential diagnosis of oncocytic renal neoplasms.Virchows Archiv : an international journal of pathology · 2025Article
- Fertility is compromised after oocyte-specific deletion of microtubule severing protein Katanin A1.Molecular human reproduction · 2025Article
- Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome.Reproduction (Cambridge, England) · 2025Article
- NPPC and AREG supplementation in IVM systems alter mRNA translation and decay programs-related gene expression in bovine COC.Animal reproduction · 2024Article
- Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction†.Biology of reproduction · 2022Review
- Follicle-stimulating hormone mediates the consumption of serum-derived glycogen by bovine cumulus-oocyte complexes duringVeterinary world · 2021Article
- Melatonin improves the first cleavage of parthenogenetic embryos from vitrified-warmed mouse oocytes potentially by promoting cell cycle progression.Journal of animal science and biotechnology · 2021Article
- Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.Nature communications · 2020Article
- Recent advances in mammalian reproductive biology.Science China. Life sciences · 2020Review
- The molecular architecture of the meiotic spindle is remodeled during metaphase arrest in oocytes.The Journal of cell biology · 2019Article
- Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis.International journal of molecular sciences · 2018Review
- The calcium-binding protein ALG-2 regulates protein secretion and trafficking via interactions with MISSL and MAP1B proteins.The Journal of biological chemistry · 2017Article
- Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.The Journal of cell biology · 2017Article
- Effect of demecolcine-assisted enucleation on the MPF level and cyclin B1 distribution in porcine oocytes.PloS one · 2014Article
- Mouse Emi2 as a distinctive regulatory hub in second meiotic metaphase.Development (Cambridge, England) · 2010Article
- Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition.BMC developmental biology · 2010Article
- Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes.PloS one · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate oocytes arrest in the second metaphase of meiosis (metaphase II [MII]) by an activity called cytostatic factor (CSF), with aligned chromosomes and stable spindles. Segregation of chromosomes occurs after fertilization. The Mos/.../MAPK (mitogen-activated protein kinases) pathway mediates this MII arrest. Using a two-hybrid screen, we identified a new MAPK partner from a mouse oocyte cDNA library. This protein is unstable during the first meiotic division and accumulates only in MII, where it localizes to the spindle. It is a substrate of the Mos/.../MAPK pathway. The depletion of endogenous RNA coding for this protein by three different means (antisense RNA, double-stranded [ds] RNA, or morpholino oligonucleotides) induces severe spindle defects specific to MII oocytes. Overexpressing the protein from an RNA not targeted by the morpholino rescues spindle destabilization. However, dsRNA has no effect on the first two mitotic divisions. We therefore have discovered a new MAPK substrate involved in maintaining spindle integrity during the CSF arrest of mouse oocytes, called MISS (for MAP kinase-interacting and spindle-stabilizing protein).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.