ArticleInfection and immunity2002
Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Bidirectional relationship between the biofilm ofMicrobiology spectrum · 2026Article
- Peri-implantitis with a potential axis to brain inflammation: an inferential review.Odontology · 2024Review
- Role of Periodontal Infection, Inflammation and Immunity in Atherosclerosis.Current problems in cardiology · 2021Review
- Oral-Gut-Brain Axis in Experimental Models of Periodontitis: Associating Gut Dysbiosis With Neurodegenerative Diseases.Frontiers in aging · 2021Review
- Alzheimer's Disease-Like Pathology Triggered byFrontiers in immunology · 2020Article
- Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14.Inflammopharmacology · 2019Article
- Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils.Cell death & disease · 2017Article
- Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection.Journal of innate immunity · 2015Article
- Periodontitis as a risk factor of atherosclerosis.Journal of immunology research · 2014Review
- How pathogen-derived cysteine proteases modulate host immune responses.Advances in experimental medicine and biology · 2011Review
- Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins.Periodontology 2000 · 2010Review
- Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2.Journal of oral microbiology · 2010Article
- Identification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells.Infection and immunity · 2009Article
- Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin.The Biochemical journal · 2009Article
- Corruption of innate immunity by bacterial proteases.Journal of innate immunity · 2009Review
- Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis.Infection and immunity · 2005Article
- In vitro models of tissue penetration and destruction by Porphyromonas gingivalis.Infection and immunity · 2004Article
- Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells.Infection and immunity · 2003Article
- Cleavage of CD14 and LBP by a protease from Prevotella intermedia.Archives of microbiology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.