Evidence map›Paper›PMID 12011028›Full record

ArticleInfection and immunity2002

Characterization of the spv locus in Salmonella enterica serovar Arizona.

Stephen J Libby, Marc Lesnick, Patricia Hasegawa, Michael Kurth, Christopher Belcher, Joshua Fierer, Donald G Guiney

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Detection ofAntibiotics (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Phylogeny ofMicrobial genomics · 2021
    Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephen J LibbyDepartment of Microbiology, North Carolina State University, Raleigh, North Carolina 27695-7615, USA.
Marc Lesnick
Patricia Hasegawa
Michael Kurth
Christopher Belcher
Joshua Fierer
Donald G Guiney
North Carolina State University · USUniversity of California, San Diego · US

Funding

TL MOLECULES AND GAMMA-DELTA T CELLSP01DK035108 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARICI, NISSI · 1986 to 2013
$19.2M
PLASMID-MEDIATED VIRULENCE IN SALMONELLAR01AI032178 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUINEY, DONALD G. · 1993 to 2008
$3.1M
Plasmid-Mediated Virulence in SalmonellaR56AI032178 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUINEY, DONALD G. · 2010 to 2010
$386k
NIAID NIH HHS AI-32178NIAID NIH HHS R01 AI032178NIAID NIH HHS R56 AI032178NIDDK NIH HHS DK35108NIDDK NIH HHS P01 DK035108
6 · The paper itself

Abstract

Salmonella enterica serovar Arizona (S. enterica subspecies IIIa) is a common Salmonella isolate from reptiles and can cause serious systemic disease in humans. The spv virulence locus, found on large plasmids in Salmonella subspecies I serovars associated with severe infections, was confirmed to be located on the chromosome of serovar Arizona. Sequence analysis revealed that the serovar Arizona spv locus contains homologues of spvRABC but lacks the spvD gene and contains a frameshift in spvA, resulting in a different C terminus. The SpvR protein functions as a transcriptional activator for the spvA promoter, and SpvB and SpvC are highly conserved. The analysis supports the proposal that the chromosomal spv sequence more closely corresponds to the ancestral locus acquired during evolution of S. enterica, with plasmid acquisition of spv genes in the subspecies I strains involving addition of spvD and polymorphisms in spvA.

Indexed as

Antigens, BacterialVirulence FactorsADP Ribose TransferasesAmino Acid SequenceAnimalsBacterial ProteinsCarrier ProteinsConserved SequenceFrameshift MutationGene DeletionHumansMolecular Sequence DataPromoter Regions, GeneticReptilesSalmonella arizonaeSalmonella InfectionsADP Ribose TransferasesAntigens, BacterialBacterial ProteinsCarrier ProteinsspvB protein, Salmonella enterica virulence plasmidSpvD protein, Salmonella entericatccA protein, IncP plasmid RK2Virulence Factors

Identifiers

PMID12011028
PMCPMC127997
OpenAlexW2107550407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.