ArticleInfection and immunity2002
Mice lacking monocyte chemoattractant protein 1 have enhanced susceptibility to an interstitial polymicrobial infection due to impaired monocyte recruitment.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- A randomized trial of an early measles vaccine at 4½ months of age in Guinea-Bissau: sex-differential immunological effects.PloS one · 2014Trial
- Monocyte chemotactic protein-1 deficiency attenuates and high-fat diet exacerbates bone loss in mice with Lewis lung carcinoma.Oncotarget · 2017Article
- Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility.Journal of dental research · 2016Article
- FOXO1 deletion reduces dendritic cell function and enhances susceptibility to periodontitis.The American journal of pathology · 2015Article
- Early Cytokine Response to Infection with Pathogenic vs Non-Pathogenic Organisms in a Mouse Model of Endodontic Infection.PloS one · 2015Article
- Pathogenic bacterial species associated with endodontic infection evade innate immune control by disabling neutrophils.Infection and immunity · 2014Article
- Article
- Review of osteoimmunology and the host response in endodontic and periodontal lesions.Journal of oral microbiology · 2011Article
- Protective role of osteopontin in endodontic infection.Immunology · 2010Article
- Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16.The Journal of allergy and clinical immunology · 2009Article
- Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- MCP-1 deficiency delays regression of pathologic retinal neovascularization in a model of ischemic retinopathy.Investigative ophthalmology & visual science · 2008Article
- Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei.Infection and immunity · 2006Article
- Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis.Infection and immunity · 2006Article
- Developing animal models for polymicrobial diseases.Nature reviews. Microbiology · 2004Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that induces monocyte recruitment in a number of different pathologies, including infection. To investigate the role of MCP-1 in protecting a host from a chronic interstitial polymicrobial infection, dental pulps of MCP-1(-/-) mice and controls were inoculated with six different oral pathogens. In this model the recruitment of leukocytes and the impact of a genetic deletion on the susceptibility to infection can be accurately assessed by measuring the progression of soft tissue necrosis and osteolytic lesion formation. The absence of MCP-1 significantly impaired the recruitment of monocytes, which at later time points was threefold higher in the wild-type mice than in MCP-1(-/-) mice (P < 0.05). The consequence was significantly enhanced rates of soft tissue necrosis and bone resorption (P < 0.05). We also determined that the MCP-1(-/-) mice were able to recruit polymorphonuclear leukocytes (PMNs) to a similar or greater extent as controls and to produce equivalent levels of Porphyromonas gingivalis-specific total immunoglobulin G (IgG) and IgG1. These results point to the importance of MCP-1 expression and monocyte recruitment in antibacterial defense and demonstrate that antibacterial defense is not due to an indirect effect on PMN recruitment or modulation of the adaptive immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.