ArticleInfection and immunity2002
Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Animal Models andJournal of clinical medicine · 2022Review
- Enhanced enzymatic production of cholesteryl 6'-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori.Journal of biomedical science · 2021Article
- Structural modifications of Helicobacter pylori lipopolysaccharide: an idea for how to live in peace.World journal of gastroenterology · 2014Review
- Prevalence of horB gene among the Helicobacter pylori strains isolated from dyspeptic patients: first report from Iran.Internal and emergency medicine · 2012Article
- Novel functions for glycosyltransferases Jhp0562 and GalT in Lewis antigen synthesis and variation in Helicobacter pylori.Infection and immunity · 2012Article
- Rodent models of Helicobacter infection, inflammation, and disease.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice.The Journal of experimental medicine · 2009Article
- Anti-Lewis X antibody promotes Helicobacter pylori adhesion to gastric epithelial cells.Infection and immunity · 2007Article
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
- Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2006Article
- Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori.Journal of bacteriology · 2005Article
- Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN.The Journal of experimental medicine · 2004Article
- Development of an interleukin-12-deficient mouse model that is permissive for colonization by a motile KE26695 strain of Helicobacter pylori.Infection and immunity · 2003Article
- Influence of Lewis antigen expression by Helicobacter pylori on bacterial internalization by gastric epithelial cells.Infection and immunity · 2003Article
- Limited role of lipopolysaccharide Lewis antigens in adherence of Helicobacter pylori to the human gastric epithelium.Infection and immunity · 2003Article
- Association of Helicobacter pylori antioxidant activities with host colonization proficiency.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
Helicobacter pylori strains frequently express Lewis X (Le(x)) and/or Le(y) on their cell surfaces as constituents of the O antigens of their lipopolysaccharide molecules. To assess the effect of Le(x) and Le(y) expression on the ability of H. pylori to colonize the mouse stomach and to adhere to epithelial cells, isogenic mutants were created in which fucT1 alone or fucT1 and fucT2, which encode the fucosyl transferases necessary for Le(x) and Le(y) expression, were deleted. C3H/HeJ mice were experimentally challenged with either wild-type 26695 H. pylori or its isogenic mutants. All strains, whether passaged in the laboratory or recovered after mouse passage, colonized the mice well and without consistent differences. During colonization by the mutants, there was no reversion to wild type. Similarly, adherence to AGS and KatoIII cells was unaffected by the mutations. Together, these findings indicate that Le expression is not necessary for mouse gastric colonization or for H. pylori adherence to epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.