ArticleInfection and immunity2002
Differential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteria.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 121 citations in OpenAlex.
- Corylin Ameliorates LPS-Induced Acute Lung Injury via Suppressing the MAPKs and IL-6/STAT3 Signaling Pathways.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Rufomycin Exhibits Dual Effects AgainstFrontiers in microbiology · 2021Article
- Fabrication of ZnO/Carbon Quantum Dots Composite Sensor for Detecting NO Gas.Sensors (Basel, Switzerland) · 2020Article
- Host cytosolic RNA sensing pathway promotes T Lymphocyte-mediated mycobacterial killing in macrophages.PLoS pathogens · 2020Article
- Extracellular vesicles deliverEMBO reports · 2019Article
- Extracellular Vesicles in Mycobacterial Infections: Their Potential as Molecule Transfer Vectors.Frontiers in immunology · 2019Review
- Mechanistic research holds promise for bacterial vaccines and phage therapies forDrug design, development and therapy · 2019Review
- Article
- Integrated miRNA and mRNA expression profiling to identify mRNA targets of dysregulated miRNAs in pulmonary tuberculosis.Epigenomics · 2018Article
- Lipids FromFrontiers in cellular and infection microbiology · 2018Article
- Striking the right immunological balance prevents progression of tuberculosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection.Scientific reports · 2017Article
- IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria.PloS one · 2017Article
- The Caenorhabditis elegans p38 MAPK Gene plays a key role in protection from mycobacteria.MicrobiologyOpen · 2016Article
- Magnesium corrosion particles do not interfere with the immune function of primary human and murine macrophages.Progress in biomaterials · 2015Article
- Mycobacterium tuberculosis PE_PGRS17 promotes the death of host cell and cytokines secretion via Erk kinase accompanying with enhanced survival of recombinant Mycobacterium smegmatis.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2013Article
- Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.PloS one · 2013Article
- Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Impaired Expression of MAPK Is Associated with the Downregulation of TNF-α, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease.Tuberculosis and respiratory diseases · 2012Article
- Exosomes released from M. tuberculosis infected cells can suppress IFN-γ mediated activation of naïve macrophages.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacteria are the etiologic agents of numerous diseases which account for significant morbidity and mortality in humans and other animal species. Many mycobacteria are intramacrophage pathogens and therefore the macrophage response to infection, which includes synthesis of cytokines such as tumor necrosis factor alpha (TNF-alpha) and production of nitric oxide, has important consequences for host immunity. However, very little is known about the macrophage cell signaling pathways initiated upon infection or how pathogenic mycobacteria may modulate the macrophage responses. Using primary murine bone marrow macrophages, we established that p38 and extracellular signal-regulated kinases 1 and 2 of the mitogen-activated protein kinase (MAPK) pathways are activated upon infection with different species of mycobacteria. However, we observed decreased MAPK activity over time in macrophages infected with pathogenic Mycobacterium avium strains relative to infections with nonpathogenic mycobacteria. Furthermore, macrophages infected with M. avium produced lower levels of TNF-alpha, interleukin 1beta, and inducible nitric oxide synthase 2 than macrophages infected with nonpathogenic species. Inhibitor studies indicate that the MAPKs are required for the Mycobacterium-mediated induction of these effector proteins. Our data indicate that MAPKs are activated in macrophages upon invasion by mycobacteria and that this activation is diminished in macrophages infected with pathogenic strains of M. avium, resulting in decreased production of important immune effector proteins. The decreased MAPK activation associated with M. avium infections suggests a novel point of immune intervention by this mycobacterial species.
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