ArticleInfection and immunity2002
Antigen-presenting cell function during Plasmodium yoelii infection.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Dendritic Cells and Their Multiple Roles during Malaria Infection.Journal of immunology research · 2016Review
- Article
- Macrophages are critical for cross-protective immunity conferred by Babesia microti against Babesia rodhaini infection in mice.Infection and immunity · 2012Article
- Dendritic cell and NK cell reciprocal cross talk promotes gamma interferon-dependent immunity to blood-stage Plasmodium chabaudi AS infection in mice.Infection and immunity · 2009Article
- A Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells.Malaria journal · 2008Article
- Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia.Infection and immunity · 2007Article
- Cytokine responses of CD4+ T cells during a Plasmodium chabaudi chabaudi (ER) blood-stage infection in mice initiated by the natural route of infection.Malaria journal · 2007Article
- Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells.The Journal of experimental medicine · 2006Article
- Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function.Journal of biology · 2006Review
- Article
- Dendritic cells induce immunity and long-lasting protection against blood-stage malaria despite an in vitro parasite-induced maturation defect.Infection and immunity · 2004Article
- Response of the splenic dendritic cell population to malaria infection.Infection and immunity · 2004Article
- Innate immunity to malaria.Nature reviews. Immunology · 2004Review
- Inhibition of T cell function during malaria: implications for immunology and vaccinology.The Journal of experimental medicine · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Antigen-presenting cells (APC) play a key role in orchestrating immune responses. T-cell proliferative responses are inhibited during the erythrocyte stages of malaria infection, and a number of studies have suggested that APC are responsible for this phenomenon. In the present studies we examine individual components of the T-cell-activating function of APC: expression of costimulatory and major histocompatibility complex (MHC) class II proteins, the ability to process and present antigen to T cells, and the ability to support cytokine production. We find that during the acute phases of Plasmodium yoelii erythrocyte stage infection, APC upregulate the expression of class II MHC and CD80, maintain expression of CD86, process and present antigen, and support gamma interferon production. However the CD11b(+) subpopulation produces a soluble factor or factors that specifically inhibit interleukin-2 (IL-2) production by responding CD4 T cells. This factor is distinct from prostaglandin E(2), NO, or transforming growth factor beta. The data suggest that IL-2 suppression observed during malaria infection is not due to functional defects of APC but is triggered by production of a factor(s) that actively suppresses production of IL-2 by T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.