ArticleInfection and immunity2002
Regulation of the overlapping pic/set locus in Shigella flexneri and enteroaggregative Escherichia coli.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Novel organisation and regulation of theVirulence · 2022Article
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- Hundreds of Out-of-Frame Remodeled Gene Families in the Escherichia coli Pangenome.Molecular biology and evolution · 2022Article
- Characterization of ShigETEC, a Novel Live Attenuated Combined Vaccine against Shigellae and ETEC.Vaccines · 2020Article
- Pathogenicity Factors of Genomic Islands in Intestinal and ExtraintestinalFrontiers in microbiology · 2020Review
- A Novel pH-Regulated, Unusual 603 bp Overlapping Protein Coding GeneFrontiers in microbiology · 2020Article
- The novel EHEC gene asa overlaps the TEGT transporter gene in antisense and is regulated by NaCl and growth phase.Scientific reports · 2018Article
- The Novel Anaerobiosis-Responsive Overlapping GeneFrontiers in microbiology · 2018Article
- A Novel pAA Virulence Plasmid Encoding Toxins and Two Distinct Variants of the Fimbriae of EnteroaggregativeFrontiers in microbiology · 2017Article
- Investigating the Relatedness of Enteroinvasive Escherichia coli to Other E. coli and Shigella Isolates by Using Comparative Genomics.Infection and immunity · 2016Article
- Unusually Situated Binding Sites for Bacterial Transcription Factors Can Have Hidden Functionality.PloS one · 2016Article
- Selection pressure in alternative reading frames.PloS one · 2014Article
- Recent advances in understanding enteric pathogenic Escherichia coli.Clinical microbiology reviews · 2013Review
- Progress and pitfalls in Shigella vaccine research.Nature reviews. Gastroenterology & hepatology · 2013Review
- A novel gene, ardD, determines antirestriction activity of the non-conjugative transposon Tn5053 and is located antisense within the tniA gene.FEMS microbiology letters · 2012Article
- Article
- A proteogenomic analysis of Shigella flexneri using 2D LC-MALDI TOF/TOF.BMC genomics · 2011Article
- Proteomic detection of non-annotated protein-coding genes in Pseudomonas fluorescens Pf0-1.PloS one · 2009Article
- The Genome Reverse Compiler: an explorative annotation tool.BMC bioinformatics · 2009Article
- New adhesin of enteroaggregative Escherichia coli related to the Afa/Dr/AAF family.Infection and immunity · 2008Article
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Authors and funding
3 authors.
Funding
Abstract
Most strains of Shigella flexneri 2a and enteroaggregative Escherichia coli carry a highly conserved chromosomal locus which encodes a 109-kDa secreted mucinase (called Pic) and, on the opposite strand in overlapping fashion, an oligomeric enterotoxin called ShET1, encoded by the setA and setB genes. Here, we characterize the genetic regulation of these overlapping genes. Our data suggest that pic and the setBA loci are transcribed as complementary 4-kb mRNA species. The major pic promoter is maximally activated at 37 degrees C in exponential growth phase. Our data suggest that the setB gene is transcribed from a promoter which lies more than 1.5 kb upstream of the setB structural gene; setA may be transcribed via readthrough of the setB transcript and possibly by its own promoter. The long leader of the setB gene provides a strong silencing effect on setB transcription. The signals which provide relief from setB silencing are not clear, but significant induction is observed in a continuous anaerobic culture of human fecal bacteria, suggesting that some complex characteristics of the human intestine act to lift repression of setB expression. Our studies provide the first insights into the mechanisms affecting expression of this unusual virulence locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.