ArticleInfection and immunity2002
The in vitro interaction of Streptococcus pyogenes with human pharyngeal cells induces a phage-encoded extracellular DNase.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Utility of Human Immune Responses to GAS Antigens as a Diagnostic Indicator for ARF: A Systematic Review.Frontiers in cardiovascular medicine · 2021Pooled it
- Nosocomial Transmission of Necrotizing Fasciitis: A Molecular Characterization of Group A Streptococcal DNases in Clinical Virulence.Microorganisms · 2024Article
- Combining bacteriophage and vancomycin is efficacious against MRSA biofilm-like aggregates formed in synovial fluid.Frontiers in medicine · 2023Article
- The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance.PLoS pathogens · 2022Article
- Characterization of the Type I Restriction Modification System Broadly Conserved among Group A Streptococci.mSphere · 2021Article
- The human oral virome: Shedding light on the dark matter.Periodontology 2000 · 2021Review
- Cryptic prophages within aMicrobial genomics · 2021Article
- Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes.Nature communications · 2020Article
- The Bacteriophages ofMicrobiology spectrum · 2019Review
- Targeted Curing of All Lysogenic Bacteriophage from Streptococcus pyogenes Using a Novel Counter-selection Technique.PloS one · 2016Article
- Bacteriophage WO Can Mediate Horizontal Gene Transfer in EndosymbioticFrontiers in microbiology · 2016Article
- Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus.Infection and immunity · 2015Article
- The prophage-encoded hyaluronate lyase has broad substrate specificity and is regulated by the N-terminal domain.The Journal of biological chemistry · 2014Article
- The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.Virulence · 2014Review
- Detection of influent virulence and resistance genes in microarray data through quasi likelihood modeling.Molecular genetics and genomics : MGG · 2013Article
- Transcriptional regulation of a bacteriophage encoded extracellular DNase (Spd-3) by Rgg in Streptococcus pyogenes.PloS one · 2013Article
- The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes.Nucleic acids research · 2012Article
- Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci.The Journal of infectious diseases · 2008Article
- Novel algorithms reveal streptococcal transcriptomes and clues about undefined genes.PLoS computational biology · 2007Article
- Why bacteriophage encode exotoxins and other virulence factors.Evolutionary bioinformatics online · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The role lysogenic bacteriophage play in the pathogenesis of the host bacterium is poorly understood. In a previous study, we found that streptococcal coculture with human pharyngeal cells resulted in the induction of lysogenic bacteriophage as well as the phage-associated streptococcal pyrogenic exotoxin C (SpeC). In this study, we have determined that in addition to SpeC induction, a number of other streptococcal proteins are also released by the bacteria during coculture with pharyngeal cells. Among these, we identified and characterized a novel 27-kDa secreted protein. Sequence analysis of this novel protein demonstrated it to be encoded by the same lysogenic bacteriophage which harbors speC. Protein sequence analysis revealed varied homologies with several streptococcal DNases. Further biochemical characterization of the recombinantly expressed protein verified it to be a divalent cation-dependent streptococcal phage-encoded DNase (Spd1). Although functionally distinct, SpeC and Spd1 are associated by a number of parameters, including genetic proximity and transcriptional regulation. Finally, we speculate on the induction of phage-encoded DNase (Spd1) enhancing the fitness of both bacteria and phage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.