ArticleInfection and immunity2002
Mapping and sequencing of the canine NRAMP1 gene and identification of mutations in leishmaniasis-susceptible dogs.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis.Parasitology research · 2019Pooled it
- The immune response in canine and human leishmaniasis and how this influences the diagnosis- a review and assessment of recent research.Frontiers in cellular and infection microbiology · 2023Review
- Immunological and genomic characterization of Ibizan Hound dogs in an endemic Leishmania infantum region.Parasites & vectors · 2022Article
- Immune and Genomic Analysis of Boxer Dog Breed and Its Relationship withVeterinary sciences · 2022Article
- Biomarkers Associated WithFrontiers in cellular and infection microbiology · 2018Review
- MYD88 and functionally related genes are associated with multiple infections in a model population of Kenyan village dogs.Molecular biology reports · 2016Article
- Genome-Wide Association Study of Cell-Mediated Response in Dogs Naturally Infected by Leishmania infantum.Infection and immunity · 2016Article
- Article
- Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease.PloS one · 2015Article
- Iron in intracellular infection: to provide or to deprive?Frontiers in cellular and infection microbiology · 2013Review
- The effect of removing potentially infectious dogs on the numbers of canine Leishmania infantum infections in an endemic area with high transmission rates.The American journal of tropical medicine and hygiene · 2012Article
- Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis.PloS one · 2012Article
- One Health: the global challenge of epidemic and endemic leishmaniasis.Parasites & vectors · 2011Review
- Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease?Proceedings. Biological sciences · 2011Article
- Immunotherapy against experimental canine visceral leishmaniasis with the saponin enriched-Leishmune vaccine.Vaccine · 2007Article
- Article
- Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis.Antimicrobial agents and chemotherapy · 2004Article
- Susceptibility to visceral leishmaniasis in the domestic dog is associated with MHC class II polymorphism.Immunogenetics · 2003Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NRAMP1 gene (Slc11a1) encodes an ion transporter protein involved in the control of intraphagosomal replication of parasites and in macrophage activation. It has been described in mice as the determinant of natural resistance or susceptibility to infection with antigenically unrelated pathogens, including Leishmania. Our aims were to sequence and map the canine Slc11a1 gene and to identify mutations that may be associated with resistance or susceptibility to Leishmania infection. The canine Slc11a1 gene has been mapped to dog chromosome CFA37 and covers 9 kb, including a 700-bp promoter region, 15 exons, and a polymorphic microsatellite in intron 1. It encodes a 547-amino-acid protein that has over 87% identity with the Slc11a1 proteins of different mammalian species. A case-control study with 33 resistant and 84 susceptible dogs showed an association between allele 145 of the microsatellite and susceptible dogs. Sequence variant analysis was performed by direct sequencing of the cDNA and the promoter region of four unrelated beagles experimentally infected with Leishmania infantum to search for possible functional mutations. Two of the dogs were classified as susceptible and the other two were classified as resistant based on their immune responses. Two important mutations were found in susceptible dogs: a G-rich region in the promoter that was common to both animals and a complete deletion of exon 11, which encodes the consensus transport motif of the protein, in the unique susceptible dog that needed an additional and prolonged treatment to avoid continuous relapses. A study with a larger dog population would be required to prove the association of these sequence variants with disease susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.