ArticleGut2002
Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.Cellular and molecular gastroenterology and hepatology · 2020Trial
- Elevated Serum Gastrin Is Associated with Melanoma Progression: Putative Role in Increased Migration and Invasion of Melanoma Cells.International journal of molecular sciences · 2023Article
- Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration.Physiological reports · 2017Article
- Article
- Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells.PloS one · 2014Article
- Effects of EGFR Inhibitor on Helicobacter pylori Induced Gastric Epithelial Pathology in Vivo.Pathogens (Basel, Switzerland) · 2013Article
- Progastrin-induced secretion of insulin-like growth factor 2 from colonic myofibroblasts stimulates colonic epithelial proliferation in mice.Gastroenterology · 2013Article
- The role of plasminogen activator inhibitor-1 in gastric mucosal protection.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Gastrin-induced proliferation involves MEK partner 1 (MP1).In vitro cellular & developmental biology. Animal · 2013Article
- The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.PloS one · 2013Article
- Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.Carcinogenesis · 2012Article
- Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).Endocrinology · 2012Article
- Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Role of bacteria in oncogenesis.Clinical microbiology reviews · 2010Review
- Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression.Pancreas · 2009Article
- Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Importance of gastrin in the pathogenesis and treatment of gastric tumors.World journal of gastroenterology · 2009Review
- The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers.Protein and peptide letters · 2009Review
- Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActivation of the gastrin-cholecystokinin(B) (CCK(B)) receptor stimulates cell proliferation and increases production of ligands for the epidermal growth factor receptor (EGF-R).
aimsTo determine the role of gastrin-CCK(B) activation in stimulation of cell proliferation via paracrine activation of EGF-R.
methodsAGS cells were transfected with the gastrin-CCK(B) receptor (AGS-G(R) cells) or with green fluorescent protein (AGS-GFP cells). Proliferation was determined by [(3)H] thymidine incorporation, flow cytometry, and cell counting.
resultsGastrin inhibited proliferation of AGS-G(R) cells by delaying entry into S phase. However, when AGS-G(R) cells were cocultured with AGS-GFP cells, gastrin stimulated proliferation of the latter. Immunoneutralisation and pharmacological studies using metalloproteinase and kinase inhibitors indicated that the proliferative response was mediated by paracrine stimulation of EGF-R and activation of the mitogen activated protein kinase pathway through release of heparin binding EGF.
conclusionsGastrin can directly inhibit, and indirectly stimulate, proliferation of gastric AGS cells.
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