ArticleGut2002
Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 246 citations in OpenAlex.
- PTGES is involved in myofibroblast differentiation via HIF-1α-dependent glycolysis pathway.Journal of cellular and molecular medicine · 2024Article
- Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives.Biomedicines · 2023Review
- A Systematic Review of the Evidence of Hematopoietic Stem Cell Differentiation to Fibroblasts.Biomedicines · 2022Review
- Stem Cell-Based Therapies for Inflammatory Bowel Disease.International journal of molecular sciences · 2022Review
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- Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation?Cancers · 2021Review
- Structural Biology of the Tumor Microenvironment.Advances in experimental medicine and biology · 2021Article
- Stromal Cells in the Pathogenesis of Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2020Review
- Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too.Digestive diseases and sciences · 2019Article
- Cellular Interactions in the Intestinal Stem Cell Niche.Archivum immunologiae et therapiae experimentalis · 2019Review
- Exploring the villus.Gastroenterology and hepatology from bed to bench · 2018Review
- Mesenchymal stromal cell therapy for the treatment of intestinal ischemia: Defining the optimal cell isolate for maximum therapeutic benefit.Cytotherapy · 2016Review
- Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.Scientific reports · 2016Article
- Serum Response Factor Is Essential for Prenatal Gastrointestinal Smooth Muscle Development and Maintenance of Differentiated Phenotype.Journal of neurogastroenterology and motility · 2015Article
- Putative intestinal stem cells.Journal of medicine and life · 2015Article
- Different Tissue-Derived Stem Cells: A Comparison of Neural Differentiation Capability.PloS one · 2015Article
- Hematopoietic stem cell transplantation for non-malignant gastrointestinal diseases.World journal of gastroenterology · 2014Review
- Article
- Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling.Translational research : the journal of laboratory and clinical medicine · 2014Article
- Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors.Journal of gastroenterology · 2014Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsIn order to establish whether extraintestinal cells contribute to the turnover and repair of gastrointestinal tissues, we studied the colons and small intestines of female mice that had received a male bone marrow transplant, together with gastrointestinal biopsies from female patients that had developed graft versus host disease after receiving a bone marrow transplant from male donors.
methodsUsing in situ hybridisation to detect Y chromosomes and immunohistochemistry, we demonstrated that cells derived from injected bone marrow frequently engrafted into the intestine and differentiated into pericryptal myofibroblasts.
resultsIn the human intestine, we confirmed by combining in situ hybridisation with immunostaining for smooth muscle actin that the bone marrow derived cells within the intestine exhibited a myofibroblast phenotype. In female mouse recipients of male bone marrow grafts, we observed colocalisation of Y chromosomes and clusters of newly formed marrow derived myofibroblasts. While few of these were present at seven days after bone marrow transplantation, they were numerous at 14 days, and by six weeks entire columns of pericryptal myofibroblasts could be seen running up the sides of crypts in both the small intestine and colon. These columns appeared to extend into the villi in the small intestine. Within the intestinal lamina propria, these Y chromosome positive cells were negative for the mouse macrophage marker F4/80 antigen and CD34.
conclusionsBone marrow derived pericryptal myofibroblasts were present in the mouse intestine following irradiation and bone marrow transplant, and in the intestines of human patients suffering graft versus host disease following a bone marrow transplant. Our data indicate that bone marrow cells contribute to the regeneration of intestinal myofibroblasts and epithelium after damage, and we suggest that this could be exploited therapeutically.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.