ArticleArthritis research2002
Tissue factor as a proinflammatory agent.
Article in Arthritis research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Tissue Factor and Its Cerebrospinal Fluid Protein Profiles in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Crosstalk between the plasminogen/plasmin system and inflammation resolution.Journal of thrombosis and haemostasis : JTH · 2023Review
- Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts.Annals of the American Thoracic Society · 2023Article
- Earliest histopathological changes in COVID-19 pneumonia with comprehensive gene expression analyses: A case series study.Histology and histopathology · 2023Article
- Expression of tissue factor and forkhead box transcription factor O-1 in a rat model for chronic thromboembolic pulmonary hypertension.Journal of thrombosis and thrombolysis · 2016Article
- The role of tissue factor and autophagy in pulmonary vascular remodeling in a rat model for chronic thromboembolic pulmonary hypertension.Respiratory research · 2016Article
- mRNA expression of genes involved in inflammation and haemostasis in equine fibroblast-like synoviocytes following exposure to lipopolysaccharide, fibrinogen and thrombin.BMC veterinary research · 2015Article
- Review
- The characteristics of thrombin in osteoarthritic pathogenesis and treatment.BioMed research international · 2014Review
- Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Induced by Urotensin II in Human Vascular Endothelial Cells.Biomolecules & therapeutics · 2013Article
- Gene promoter methylation is associated with lung function in the elderly: the Normative Aging Study.Epigenetics · 2012Article
- Circulating tissue factor procoagulant activity is elevated in stable moderate to severe chronic obstructive pulmonary disease.Thrombosis research · 2009Article
- Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule.Lupus · 2008Review
- Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation.Arthritis research & therapy · 2008Article
- Article
- Shiga toxin 2 and lipopolysaccharide induce human microvascular endothelial cells to release chemokines and factors that stimulate platelet function.Infection and immunity · 2005Article
- The procoagulant potential of environmental particles (PM10).Occupational and environmental medicine · 2005Article
- What do we mean by the term "inflammation"? A contemporary basic science update for sports medicine.British journal of sports medicine · 2004Review
- Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice.The American journal of pathology · 2004Article
- Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils.The Journal of experimental medicine · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Tissue factor (TF) is a transmembrane glycoprotein and the main triggering element of blood coagulation. TF expression on monocytes and endothelial cells is induced by exposure to endotoxin, tumor necrosis factor, and IL-1 and is considered to appear in consequence of inflammation. In order to assess the proinflammatory capacity of TF itself, the recombinant extracellular domain of TF was injected intra-articularly into healthy mice. To characterize the role of immune cells in the TF-induced arthritis, mice deprived of lymphocytes, neutrophils and monocytes were used. Histomorphological analysis of the joints with respect to inflammatory cell infiltration, pannus formation and erosion formation revealed development of arthritis in 80% of animals injected with TF. In most of the cases synovial proliferation was accompanied by pannus formation and cartilage destruction. Inflammatory cell infiltrate consisted of CD4-Mac1+ macrophages. Depletion of monocytes was, however, not enough to abolish inflammation. Indeed, combined deficiency of monocytes and lymphocytes was required to prevent inflammation following the injection of TF. We observed that TF induced chemokine production (MIP-1alpha and RANTES), but did not induce a proliferative response nor cytokine release by mouse spleen cells. TF has strong inflammatogenic properties mediated predominantly by monocytes and their release of chemokines. Our study shows that TF can simultaneously trigger the immune and coagulation systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.