ArticleMolecular biology of the cell2002
Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 76 citations in OpenAlex.
- ORChestra coordinates the replication and repair music.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I.Cell chemical biology · 2020Article
- Activation of Checkpoint Kinase Chk1 by Reactive Oxygen Species Resulting from Disruption of wat1/pop3 in Schizosaccharomyces pombe.Genetics · 2016Article
- External and internal triggers of cell death in yeast.Cellular and molecular life sciences : CMLS · 2016Review
- Boolean model of yeast apoptosis as a tool to study yeast and human apoptotic regulations.Frontiers in physiology · 2012Article
- Oxidative stress and programmed cell death in yeast.Frontiers in oncology · 2012Article
- Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.The Journal of biological chemistry · 2011Article
- Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants.International journal of molecular sciences · 2009Review
- Replication licensing and the DNA damage checkpoint.Frontiers in bioscience (Landmark edition) · 2009Review
- Apoptotic death of ageing yeast.Experimental gerontology · 2008Review
- Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.The Journal of biological chemistry · 2008Article
- Genetic and proteomic analyses of a proteasome-activating nucleotidase A mutant of the haloarchaeon Haloferax volcanii.Journal of bacteriology · 2008Article
- A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage.Molecular biology of the cell · 2007Article
- Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.The Journal of cell biology · 2006Article
- Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis.Journal of cell science · 2006Article
- Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging.Molecular biology of the cell · 2006Article
- Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.Journal of cell science · 2006Article
- Yeast caspase 1 links messenger RNA stability to apoptosis in yeast.EMBO reports · 2005Article
- Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast.The Journal of cell biology · 2005Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The highly conserved Cdc6 protein is required for initiation of eukaryotic DNA replication and, in yeast and Xenopus, for the coupling of DNA replication to mitosis. Herein, we show that human Cdc6 is rapidly destroyed by a p53-independent, proteasome-, and ubiquitin-dependent pathway during early stages of programmed cell death induced by the DNA-damaging drug adozelesin, or by a separate caspase-dependent pathway in cells undergoing apoptosis through an extrinsic pathway induced by tumor necrosis factor-alpha and cycloheximide. The proteasome-dependent pathway induced by adozelesin is conserved in the budding yeast Saccharomyces cerevisiae. The destruction of Cdc6 may be a primordial programmed death response that uncouples DNA replication from the cell division cycle, which is reinforced in metazoans by the evolution of caspases and p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.