ArticleThe EMBO journal2002
The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic Progression.Journal of developmental biology · 2026Review
- Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes.Nature communications · 2025Article
- Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins.International journal of molecular sciences · 2023Review
- Translational Control ofCells · 2020Review
- An interaction between myosin-10 and the cell cycle regulator Wee1 links spindle dynamics to mitotic progression in epithelia.The Journal of cell biology · 2018Article
- Cell cycle control in the early embryonic development of aquatic animal species.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Review
- Dual phosphorylation of cdk1 coordinates cell proliferation with key developmental processes in Drosophila.Genetics · 2014Article
- Gonadal transcriptome analysis of male and female olive flounder (Paralichthys olivaceus).BioMed research international · 2014Article
- Regulation of oocyte meiotic maturation by somatic cells.Reproductive medicine and biology · 2012Article
- WEE2 is an oocyte-specific meiosis inhibitor in rhesus macaque monkeys.Biology of reproduction · 2010Article
- Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry.Cell division · 2010Article
- Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts.Molecular cell · 2010Article
- Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption.The Journal of cell biology · 2010Article
- Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development.Genetics · 2008Article
- Cdc25 and Wee1: analogous opposites?Cell division · 2007Article
- Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Multisite M-phase phosphorylation of Xenopus Wee1A.Molecular and cellular biology · 2005Article
- Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.The EMBO journal · 2004Article
- Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation.Molecular biology of the cell · 2004Article
- M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic cells, the Wee1 protein kinase phosphorylates and inhibits Cdc2, thereby creating an interphase of the cell cycle. In Xenopus, the conventional Wee1 homolog (termed Xe-Wee1A, or Wee1A for short) is maternally expressed and functions in pregastrula embryos with rapid cell cycles. Here, we have isolated a second, zygotic isoform of Xenopus Wee1, termed Xe-Wee1B (or Wee1B for short), that is expressed in postgastrula embryos and various adult tissues. When ectopically expressed in immature oocytes, Wee1B inhibits Cdc2 activity and oocyte maturation (or entry into M phase) much more strongly than Wee1A, due to its short C-terminal regulatory domain. Moreover, ectopic Wee1B, unlike Wee1A, is very labile during meiosis II and cannot accumulate in mature oocytes due to the presence of PEST-like sequences in its N-terminal regulatory domain. Finally, when expressed in fertilized eggs, ectopic Wee1B but not Wee1A does affect cell division and impair cell viability in early embryos, due primarily to its very strong kinase activity. These results suggest strongly that the differential expression of Wee1A and Wee1B is crucial for the developmental regulation of the cell cycle in Xenopus.
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