ReviewThe Biochemical journal2002
G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes.
Review in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Overexpression of mGluMolecular neurobiology · 2025Article
- Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders.Molecular pharmacology · 2024Review
- Functional Cross-Talk between Adenosine and Metabotropic Glutamate Receptors.Current neuropharmacology · 2019Review
- Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer's Disease Mouse Model.Journal of Alzheimer's disease : JAD · 2016Article
- MAS C-Terminal Tail Interacting Proteins Identified by Mass Spectrometry- Based Proteomic Approach.PloS one · 2015Article
- The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization.The Journal of biological chemistry · 2013Article
- Regulation of metabotropic glutamate receptor 7 (mGluR7) internalization and surface expression by Ser/Thr protein phosphatase 1.The Journal of biological chemistry · 2013Article
- Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity.Advances in pharmacology (San Diego, Calif.) · 2011Review
- Beyond desensitization: physiological relevance of arrestin-dependent signaling.Pharmacological reviews · 2010Review
- Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.Molecular pharmacology · 2010Article
- Metabotropic glutamate receptors: physiology, pharmacology, and disease.Annual review of pharmacology and toxicology · 2010Review
- Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7.The Journal of biological chemistry · 2008Article
- Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- PICK1 uncoupling from mGluR7a causes absence-like seizures.Nature neuroscience · 2008Article
- A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors.Molecular & cellular proteomics : MCP · 2008Article
- Article
- Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle.Genome biology · 2008Article
- Calmodulin interacts with the platelet ADP receptor P2Y1.The Biochemical journal · 2006Article
- Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis.The EMBO journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G-protein-coupled receptors (GPCRs) represent a superfamily of highly diverse integral membrane proteins that transduce external signals to different subcellular compartments, including nuclei, via trimeric G-proteins. By differential activation of diffusible G(alpha) and membrane-bound G(beta)gamma subunits, GPCRs might act on both cytoplasmic/intracellular and plasma-membrane-bound effector systems. The coupling efficiency and the plasma membrane localization of GPCRs are regulated by a variety of interacting proteins. In this review, we discuss recently disclosed protein interactions found with the cytoplasmic C-terminal tail regions of two types of presynaptic neurotransmitter receptors, the group III metabotropic glutamate receptors and the gamma-aminobutyric acid type-B receptors (GABA(B)Rs). Calmodulin binding to mGluR7 and other group III mGluRs may provide a Ca(2+)-dependent switch for unidirectional (G(alpha)) versus bidirectional (G(alpha) and G(beta)gamma) signalling to downstream effector proteins. In addition, clustering of mGluR7 by PICK1 (protein interacting with C-kinase 1), a polyspecific PDZ (PSD-95/Dlg1/ZO-1) domain containing synaptic organizer protein, sheds light on how higher-order receptor complexes with regulatory enzymes (or 'signalosomes') could be formed. The interaction of GABA(B)Rs with the adaptor protein 14-3-3 and the transcription factor ATF4 (activating transcription factor 4) suggests novel regulatory pathways for G-protein signalling, cytoskeletal reorganization and nuclear gene expression: processes that may all contribute to synaptic plasticity.
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