ArticleBMC endocrine disorders2002
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.
Article in BMC endocrine disorders, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.Cellular and molecular life sciences : CMLS · 2023Article
- Bayesian hierarchical models for high-dimensional mediation analysis with coordinated selection of correlated mediators.Statistics in medicine · 2021Article
- Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress.Redox biology · 2020Article
- Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in PancreaticJournal of diabetes research · 2020Review
- O-GlcNAcylation of 8-Oxoguanine DNA Glycosylase (Ogg1) Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts.The Journal of biological chemistry · 2016Article
- Detection of DNA damage in peripheral blood mononuclear cells from pancreatic cancer patients.Molecular carcinogenesis · 2015Article
- In Vitro Fluorogenic Real-Time Assay of the Repair of Oxidative DNA Damage.Chembiochem : a European journal of chemical biology · 2015Article
- Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice.The Journal of biological chemistry · 2014Article
- Article
- Altered expression of base excision repair genes in response to high glucose-induced oxidative stress in HepG2 hepatocytes.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria.The American journal of pathology · 2011Article
- 8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress.Free radical biology & medicine · 2010Article
- Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation.Atherosclerosis · 2010Article
- Islet specific Wnt activation in human type II diabetes.Experimental diabetes research · 2008Article
- Chromosomal telomere attrition as a mechanism for the increased risk of epithelial cancers and senescent phenotypes in type 2 diabetes.Diabetologia · 2006Review
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has become increasingly clear that beta-cell failure plays a critical role in the pathogenesis of type 2 diabetes. Free-radical mediated beta-cell damage has been intensively studied in type 1 diabetes, but not in human type 2 diabetes. Therefore, we studied the protein expression of the DNA repair enzyme Ogg1 in pancreases from type 2 diabetics. Ogg1 was studied because it is the major enzyme involved in repairing 7,8-dihydro-8-oxoguanosine DNA adducts, a lesion previously observed in a rat model of type 2 diabetes. Moreover, in a gene expression screen, Ogg1 was over-expressed in islets from a human type 2 diabetic.
methodsImmunofluorescent staining of Ogg1 was performed on pancreatic specimens from healthy controls and patients with diabetes for 2-23 years. The intensity and islet area stained for Ogg1 was evaluated by semi-quantitative scoring.
resultsBoth the intensity and the area of islet Ogg1 staining were significantly increased in islets from the type 2 diabetic subjects compared to the healthy controls. A correlation between increased Ogg1 fluorescent staining intensity and duration of diabetes was also found. Most of the staining observed was cytoplasmic, suggesting that mitochondrial Ogg1 accounts primarily for the increased Ogg1 expression.
conclusionWe conclude that oxidative stress related DNA damage may be a novel important factor in the pathogenesis of human type 2 diabetes. An increase of Ogg1 in islet cell mitochondria is consistent with a model in which hyperglycemia and consequent increased beta-cell oxidative metabolism lead to DNA damage and the induction of Ogg1 expression.
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