ArticleThe American journal of pathology2002
Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Metabolic crosstalk between skeletal muscle and cartilage tissue: insights into myokines in osteoarthritis.Molecular biology reports · 2025Review
- Oncostatin M: Dual Regulator of the Skeletal and Hematopoietic Systems.Current osteoporosis reports · 2024Review
- Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis.Cytokine · 2022Article
- Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator.International journal of molecular sciences · 2022Review
- Article
- A roadmap to target interleukin-6 in osteoarthritis.Rheumatology (Oxford, England) · 2020Article
- Impact of Bacterial Infections on Osteogenesis: Evidence From In Vivo Studies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- Macrophages and skeletal health.Pharmacology & therapeutics · 2017Review
- Effects of oncostatin M on cell proliferation and osteogenic differentiation in C3H10T1/2.Journal of musculoskeletal & neuronal interactions · 2016Article
- Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation.Arthritis research & therapy · 2016Article
- Macrophage Polarization and Bone Formation: A review.Clinical reviews in allergy & immunology · 2016Review
- The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation.PloS one · 2015Article
- Fuzzy clustering analysis of osteosarcoma related genes.Pathology oncology research : POR · 2014Article
- The enigmatic cytokine oncostatin m and roles in disease.ISRN inflammation · 2013Review
- Metastasin S100A4 is a mediator of sex hormone-dependent formation of the cortical bone.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.PloS one · 2012Article
- Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines.BMC cancer · 2011Article
- Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.The Journal of clinical investigation · 2010Article
- Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation.The American journal of pathology · 2009Article
- A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.Arthritis research & therapy · 2005Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncostatin M (OSM) has been described as a bone-remodeling factor either stimulating osteoblast activity or osteoclast formation in vitro. To elucidate the in vivo effect of OSM on bone remodeling, we injected an adenoviral vector encoding murine OSM in knee joints of mice. OSM strongly induced interleukin (IL)-6 gene expression, a known mediator of osteoclast development. We investigated the OSM effect in wild-type and IL-6-deficient mice and found a similar degree of OSM-induced joint inflammation. Within the first week of inflammation, the periosteum along the femur and tibia increased in cell number and stained positive for the osteoblast marker alkaline phosphatase. At these sites bone apposition occurred in both strains as demonstrated by Goldner and Von Kossa staining. In vitro OSM enhanced the effect of bone morphogenetic protein-2 on osteoblast differentiation. Immunohistochemistry demonstrated expression of receptor activator of nuclear factor-kappa B ligand (RANKL) and its receptor, receptor activator of nuclear factor-kappa B (RANK), in the periosteum but osteoclasts were not detected at sites of bone apposition. Induced mRNA expression for the receptor activator of nuclear factor-kappa B ligand inhibitor osteoprotegerin probably controlled osteoclast development during OSM overexpression. Our results show that OSM favors bone apposition at periosteal sites instead of resorption in vivo. This effect was not dependent on or inhibited by IL-6.
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Registered trials
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