ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2002
Altered eosinophil levels as a result of viral infection in asthma exacerbation in childhood.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- Alveolar Macrophages in Viral Respiratory Infections: Sentinels and Saboteurs of Lung Defense.International journal of molecular sciences · 2025Review
- Review
- Selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia: a cross-sectional study.BMC pulmonary medicine · 2022Article
- Knowledge, attitude and practices of PHC physicians in Aseer region regarding management of acute asthma.Journal of family medicine and primary care · 2021Article
- Respiratory pathogens and clinical outcomes in children with an asthma exacerbation: A systematic review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2019Review
- Dual effects of respiratory syncytial virus infections on airway inflammation by regulation of Th17/Treg responses in ovalbumin-challenged mice.Inflammation · 2014Article
- Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Impact of yoga on biochemical profile of asthmatics: A randomized controlled study.International journal of yoga · 2014Article
- Article
- Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration.Journal of leukocyte biology · 2013Article
- Respiratory syncitial virus in children with acute respiratory infections.Indian journal of pediatrics · 2010Article
- The role of chemokines in virus-associated asthma exacerbations.Current allergy and asthma reports · 2008Review
- Understanding the mechanisms of viral induced asthma: new therapeutic directions.Pharmacology & therapeutics · 2008Review
- A database for medicinal plants used in treatment of asthma.Bioinformation · 2007Article
- Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response.The Journal of allergy and clinical immunology · 2006Review
- Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice.Virology journal · 2006Article
- Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways.American journal of respiratory cell and molecular biology · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory viral infection is known to be a significant cause of asthma exacerbation. Eosinophils have been considered to play an important role in the pathogenesis of virus-induced asthma exacerbations. To determine how often asthma exacerbation is caused by virus infections and to examine the relationship between eosinophilia and asthma episode, we investigated 64 children who experienced asthma attacks between October 1999 and March 2000. We used rapid enzyme immunoassays to detect antigens of respiratory syncytial virus (RSV), influenza A virus, and adenovirus in nasopharyngeal secretions (NPS) of these children, and enumerated eosinophils in the blood and NPS. We detected RSV in 27% and influenza A virus in 17% of the patients. No adenovirus infection or RSV/influenza A co-infection was detected. RSV-infected children were younger (3.85 +/- 0.83 years old) than influenza A virus-infected patients (5.23 +/- 1.34 years old). Eighty-two per cent of patients in the RSV group and 36% of patients in the influenza A virus group had moderate-to-severe asthma episodes (p < 0.05). In RSV-infected children, the eosinophil counts in NPS were higher in the 'severe' group, and younger patients had a greater number of eosinophils in their NPS than older patients (p < 0.05). These trends were not found in influenza A virus patients. In conclusion, our results indicate that, compared with influenza A virus-induced asthma attacks, RSV infection had a higher probability of being associated with asthma exacerbation in infants and younger children and induced attacks of greater severity. The increase in the number of eosinophils in the NPS of RSV-infected children may be responsible, in part, for these differences.
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