ArticlePlant molecular biology
QTL analysis of proteome and transcriptome variations for dissecting the genetic architecture of complex traits in maize.
Article in Plant molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- A meta-analysis strategy for gene prioritization using gene expression, SNP genotype, and eQTL data.BioMed research international · 2015Pooled it
- Systems and Synthetic Biology of Forest Trees: A Bioengineering Paradigm for Woody Biomass Feedstocks.Frontiers in plant science · 2019Review
- Deciphering mechanisms underlying the genetic variation of general production and liver quality traits in the overfed mule duck by pQTL analyses.Genetics, selection, evolution : GSE · 2017Article
- Functional relevance for multiple sclerosis-associated genetic variants.Immunogenetics · 2015Article
- Systems genetics in "-omics" era: current and future development.Theory in biosciences = Theorie in den Biowissenschaften · 2013Review
- seeQTL: a searchable database for human eQTLs.Bioinformatics (Oxford, England) · 2012Article
- Identification of tillering node proteins differentially accumulated in barley recombinant inbred lines with different juvenile growth habits.International journal of molecular sciences · 2012Article
- Integration of the barley genetic and seed proteome maps for chromosome 1H, 2H, 3H, 5H and 7H.Functional & integrative genomics · 2009Article
- Estimation of multilocus linkage disequilibria in diploid populations with dominant markers.Genetics · 2007Article
- Quantitative trait loci for early plant vigour of maize grown in chilly environments.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2007Article
- A new strategy for estimating recombination fractions between dominant markers from an F2 population.Genetics · 2007Article
- A large-sample QTL study in mice: II. Body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila.Genetics · 2003Article
- Mapping QTLs regulating morpho-physiological traits and yield: case studies, shortcomings and perspectives in drought-stressed maize.Annals of botany · 2002Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this review, we present some studies on genetic analysis of proteome and transcriptome variations, which exemplify new strategies for a better understanding of the molecular and genetic bases of complex traits. A large genetic variability was revealed at the proteome expression level, which raised the possibility to predict phenotypical performance on the basis of gene product variability. This approach yielded limited results, but could be re-newed by extensive identification of proteins now allowed by mass spectrometry. The dissection of the genetic basis of the variation of individual protein amounts proves very powerful to select 'candidate' proteins, physiologically relevant for a given phenotypical trait, as shown by a study on the effect of water stress in maize. In order to investigate factors of grain quality in maize, we selected a regulatory locus known to control the expression of several storage protein genes, Opaque-2, and investigated the relationships between variability in zein amount and composition and the molecular polymorphism at this locus. Moreover, a QTL analysis revealed that the variability in Opaque-2 transcript abundance was controlled by several polymorphic trans-acting regulators unlinked to the Opaque-2 structural gene. Such genetic approaches should represent additional tools for physiological analysis of the huge amounts of data generated by transcritome and proteome projects.
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