ArticleMolecular and cellular biology2002
A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 115 citations in OpenAlex.
- Chicken IRF10 suppresses the cGAS-STING-IFN antiviral signaling pathway by targeting IRF7.Frontiers in immunology · 2026Article
- Article
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- Dietary Black Soldier Fly (Insects · 2024Article
- Article
- Interferon regulatory factor 7 in inflammation, cancer and infection.Frontiers in immunology · 2023Review
- Negative regulation of interferon regulatory factor 6 (IRF6) in interferon and NF-κB signalling pathways of common carp (Cyprinus carpio L.).BMC veterinary research · 2022Article
- Functional characterization of goose IRF1 in IFN induction and anti-NDV infection.Veterinary research · 2022Article
- Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response.BMC veterinary research · 2020Article
- Review
- Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease.Oncotarget · 2016Review
- Article
- Functional Analysis of Chicken IRF7 in Response to dsRNA Analog Poly(I:C) by Integrating Overexpression and Knockdown.PloS one · 2015Article
- Gene cloning and induced expression pattern of IRF4 and IRF10 in the Asian swamp eel (Monopterus albus).Dong wu xue yan jiu = Zoological research · 2014Article
- A murrel interferon regulatory factor-1: molecular characterization, gene expression and cell protection activity.Molecular biology reports · 2014Article
- Regulation of T helper cell differentiation by interferon regulatory factor family members.Immunologic research · 2012Review
- IRF7: activation, regulation, modification and function.Genes and immunity · 2011Review
- Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution.BMC immunology · 2010Article
- Dynamic evolution of immune system regulators: the history of the interferon regulatory factor family.Molecular biology and evolution · 2009Article
- Interferon regulatory factors (IRFs) repress transcription of the chicken ovalbumin gene.Gene · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cloning and functional characterization of a novel interferon regulatory factor (IRF), IRF-10, are described. IRF-10 is most closely related to IRF-4 but differs in both its constitutive and inducible expression. The expression of IRF-10 is inducible by interferons (IFNs) and by concanavalin A. In contrast to that of other IRFs, the inducible expression of IRF-10 is characterized by delayed kinetics and requires protein synthesis, suggesting a unique role in the later stages of an antiviral defense. Accordingly, IRF-10 is involved in the upregulation of two primary IFN-gamma target genes (major histocompatibility complex [MHC] class I and guanylate-binding protein) and interferes with the induction of the type I IFN target gene for 2',5'-oligo(A) synthetase. IRF-10 binds the interferon-stimulated response element site of the MHC class I promoter. In contrast to that of IRF-1, which has some of the same functional characteristics, the expression of IRF-10 is not cytotoxic for fibroblasts or B cells. The expression of IRF-10 is induced by the oncogene v-rel, the proto-oncogene c-rel, and IRF-4 in a tissue-specific manner. Moreover, v-Rel and IRF-4 synergistically cooperate in the induction of IRF-10 in fibroblasts. The level of IRF-10 induction in lymphoid cell lines by Rel proteins correlates with Rel transformation potential. These results suggest that IRF-10 plays a role in the late stages of an immune defense by regulating the expression some of the IFN-gamma target genes in the absence of a cytotoxic effect. Furthermore, IRF-10 expression is regulated, at least in part, by members of the Rel/NF-kappa B and IRF families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.