ArticleMolecular and cellular biology2002
Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- PU.1 and TGF-β signaling activate the cell-surface expression of CD103 in mast cells and dendritic cells: opposite roles of GATA2 in the expression of mucosal mast cell genes.The FEBS journal · 2025Article
- GATA2 decommissioning of enhancers: A mechanism to constrain inflammatory signaling.Cell reports · 2025Article
- HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia.Nucleic acids research · 2022Article
- Article
- Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies.Signal transduction and targeted therapy · 2021Review
- Hematopoietic Stem Cell Transcription Factors in Cardiovascular Pathology.Frontiers in genetics · 2020Review
- CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging.Neurobiology of aging · 2013Article
- Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia.Nucleic acids research · 2012Article
- Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.PloS one · 2012Article
- Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site.PloS one · 2011Article
- Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification.Journal of biomedicine & biotechnology · 2011Review
- Article
- GATA Transcription Factors and Cancer.Genes & cancer · 2010Article
- Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging.The Kaohsiung journal of medical sciences · 2010Review
- Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells.Immunogenetics · 2010Article
- Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.Blood · 2009Article
- Review
- TLX1/HOX11-induced hematopoietic differentiation blockade.Oncogene · 2007Article
- PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure.The EMBO journal · 2005Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Aberrant expression of PU.1 inhibits erythroid cell differentiation and contributes to the formation of murine erythroleukemias (MEL). The molecular mechanism by which this occurs is poorly understood. Here we show that PU.1 specifically and efficiently inhibits CBP-mediated acetylation of several nuclear proteins, including the hematopoietic transcription factors GATA-1, NF-E2, and erythroid Krüppel-like factor. In addition, PU.1 blocks acetylation of histones and interferes with acetylation-dependent transcriptional events. CBP acetyltransferase activity increases during MEL cell differentiation as PU.1 levels decline and is inhibited by sustained PU.1 expression. Finally, PU.1 inhibits the differentiation-associated increase in histone acetylation at an erythroid-specific gene locus in vivo. Together, these findings suggest that aberrant expression of PU.1 and possibly other members of the Ets family of oncoproteins subverts normal cellular differentiation in part by inhibiting the acetylation of critical nuclear factors involved in balancing cellular proliferation and maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.