ArticleMolecular and cellular biology2002
The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Single-cell multi-omics sequencing reveals cell-specific transcriptomic and chromatin accessibility profiles in gut microbiome metabolite butyrate-produced pain modulation.International journal of oral science · 2026Article
- Transcriptional patterns of cancer-related genes in primary and metastatic tumours revealed by machine learning.BMC biology · 2025Article
- MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis.Cell death & disease · 2017Review
- Phosphorylation of the transcriptional repressor MYB15 by mitogen-activated protein kinase 6 is required for freezing tolerance in Arabidopsis.Nucleic acids research · 2017Article
- Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.Scientific reports · 2017Article
- Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.American journal of clinical and experimental urology · 2014Review
- B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.Cell death & disease · 2013Article
- Molecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene Expression Analysis.Bioinformatics and biology insights · 2013Article
- B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).Cell cycle (Georgetown, Tex.) · 2012Article
- Article
- MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesis.BMC developmental biology · 2011Article
- Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1.The Journal of biological chemistry · 2008Article
- B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells.PloS one · 2008Article
- A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.The EMBO journal · 2007Article
- The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis.The EMBO journal · 2007Article
- The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3.Molecular biology of the cell · 2005Article
- Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways.The Journal of biological chemistry · 2004Article
- Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication.Genes & development · 2004Article
- The cooperation of B-Myb with the coactivator p300 is orchestrated by cyclins A and D1.Oncogene · 2004Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The B-Myb transcription factor has been implicated in coordinating the expression of genes involved in cell cycle regulation. Although it is expressed in a ubiquitous manner, its transcriptional activity is repressed until the G(1)-S phase of the cell cycle by an unknown mechanism. In this study we used biochemical and cell-based assays to demonstrate that the nuclear receptor corepressors N-CoR and SMRT interact with B-Myb. The significance of these B-Myb-corepressor interactions was confirmed by the finding that B-Myb mutants, which were unable to bind N-CoR, exhibited constitutive transcriptional activity. It has been shown previously that phosphorylation of B-Myb by cdk2/cyclin A enhances its transcriptional activity. We have now determined that phosphorylation by cdk2/cyclin A blocks the interaction between B-Myb and N-CoR and that mutation of the corepressor binding site within B-Myb bypasses the requirement for this phosphorylation event. Cumulatively, these findings suggest that the nuclear corepressors N-CoR and SMRT serve a previously unappreciated role as regulators of B-Myb transcriptional activity.
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