ArticleMolecular and cellular biology2002
Nucleosome remodeling by the human SWI/SNF complex requires transient global disruption of histone-DNA interactions.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Generating specificity in genome regulation through transcription factor sensitivity to chromatin.Nature reviews. Genetics · 2022Review
- Reb1, Cbf1, and Pho4 Bias Histone Sliding and Deposition Away from Their Binding Sites.Molecular and cellular biology · 2022Article
- Emerging Themes in Mechanisms of Tumorigenesis by SWI/SNF Subunit Mutation.Epigenetics insights · 2022Review
- High precision FRET studies reveal reversible transitions in nucleosomes between microseconds and minutes.Nature communications · 2018Article
- Mechanisms of ATP-Dependent Chromatin Remodeling Motors.Annual review of biophysics · 2016Review
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- Article
- Transcriptional Enhancers in the Regulation of T Cell Differentiation.Frontiers in immunology · 2015Review
- Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection.Frontiers in immunology · 2012Article
- SWI/SNF- and RSC-catalyzed nucleosome mobilization requires internal DNA loop translocation within nucleosomes.Molecular and cellular biology · 2011Article
- Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientation.The Journal of biological chemistry · 2011Article
- Histone tyrosine phosphorylation comes of age.Epigenetics · 2011Review
- Mechanism(s) of SWI/SNF-induced nucleosome mobilization.Chembiochem : a European journal of chemical biology · 2011Review
- Transcription dynamics.Molecular cell · 2009Review
- Human SWI/SNF directs sequence-specific chromatin changes on promoter polynucleosomes.Nucleic acids research · 2008Article
- Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.Carcinogenesis · 2008Article
- A conserved Swi2/Snf2 ATPase motif couples ATP hydrolysis to chromatin remodeling.Molecular and cellular biology · 2005Article
- Using atomic force microscopy to study nucleosome remodeling on individual nucleosomal arrays in situ.Biophysical journal · 2004Article
- Crystal structures of histone Sin mutant nucleosomes reveal altered protein-DNA interactions.The EMBO journal · 2004Article
- Dynamic properties of nucleosomes during thermal and ATP-driven mobilization.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We utilized a site-specific cross-linking technique to investigate the mechanism of nucleosome remodeling by hSWI/SNF. We found that a single cross-link between H2B and DNA virtually eliminates the accumulation of stably remodeled species as measured by restriction enzyme accessibility assays. However, cross-linking the histone octamer to nucleosomal DNA does not inhibit remodeling as monitored by DNase I digestion assays. Importantly, we found that the restriction enzyme-accessible species can be efficiently cross-linked after remodeling and that the accessible state does not require continued ATP hydrolysis. These results imply that the generation of stable remodeled states requires at least transient disruption of histone-DNA interactions throughout the nucleosome, while hSWI/SNF-catalyzed disruption of just local histone-DNA interactions yields less-stable remodeled states that still display an altered DNase I cleavage pattern. The implications of these results for models of the mechanism of SWI/SNF-catalyzed nucleosome remodeling are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.