ArticleProceedings of the National Academy of Sciences of the United States of America2002
Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 96 citations in OpenAlex.
- Cardiac unloading models for myocardial reverse remodeling.Basic research in cardiology · 2026Review
- Article
- Reverse Remodeling With Left Ventricular Assist Devices.Circulation research · 2021Review
- Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors.Hypertension (Dallas, Tex. : 1979) · 2016Article
- The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure.Circulation research · 2014Review
- Impact of aldosterone antagonists on the substrate for atrial fibrillation: aldosterone promotes oxidative stress and atrial structural/electrical remodeling.International journal of cardiology · 2013Review
- Expression profiling of nuclear receptors identifies key roles of NR4A subfamily in uterine fibroids.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Mineralocorticoid-receptor antagonists in heart failure: a tale of serendipity and success.Current heart failure reports · 2011Article
- A murine model of isolated cardiac steatosis leads to cardiomyopathy.Hypertension (Dallas, Tex. : 1979) · 2011Article
- This is not Dr. Conn's aldosterone anymore.Transactions of the American Clinical and Climatological Association · 2011Review
- Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism.American journal of physiology. Heart and circulatory physiology · 2009Article
- Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease.British journal of pharmacology · 2009Review
- Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2009Article
- Nuclear receptors: decoding metabolic disease.FEBS letters · 2008Review
- The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.Nuclear receptor signaling · 2007Review
- Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective?British journal of pharmacology · 2005Article
- Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias.Circulation · 2005Article
- Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.British journal of pharmacology · 2005Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac failure is a common feature in the evolution of cardiac disease. Among the determinants of cardiac failure, the renin-angiotensin-aldosterone system has a central role, and antagonism of the mineralocorticoid receptor (MR) has been proposed as a therapeutic strategy. In this study, we questioned the role of the MR, not of aldosterone, on heart function, using an inducible and cardiac-specific transgenic mouse model. We have generated a conditional knock-down model by expressing solely in the heart an antisense mRNA directed against the murine MR, a transcription factor with unknown targets in cardiomyocytes. Within 2-3 mo, mice developed severe heart failure and cardiac fibrosis in the absence of hypertension or chronic hyperaldosteronism. Moreover, cardiac failure and fibrosis were fully reversible when MR antisense mRNA expression was subsequently suppressed.
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