ArticleGenome research2002
Analyses of the extent of shared synteny and conserved gene orders between the genome of Fugu rubripes and human 20q.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
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- Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates.Frontiers in neuroscience · 2015Article
- PTGBase: an integrated database to study tandem duplicated genes in plants.Database : the journal of biological databases and curation · 2015Article
- Polyploidy-associated genome modifications during land plant evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene.BMC evolutionary biology · 2013Article
- PGDD: a database of gene and genome duplication in plants.Nucleic acids research · 2013Article
- Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Cladogenetic correlates of genomic expansions in the recent evolution of actinopterygiian fishes.Proceedings. Biological sciences · 2006Article
- Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny.Immunogenetics · 2005Article
- Evolution of the Beckwith-Wiedemann syndrome region in vertebrates.Genome research · 2005Article
- Major events in the genome evolution of vertebrates: paranome age and size differ considerably between ray-finned fishes and land vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.Development genes and evolution · 2004Article
- A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes.Nucleic acids research · 2004Article
- Strong conservation of the human NF2 locus based on sequence comparison in five species.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
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- Theatre: A software tool for detailed comparative analysis and visualization of genomic sequence.Nucleic acids research · 2003Article
- Modularity and reshuffling of Snail and Slug expression during vertebrate evolution.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cosmid and BAC contig maps have been constructed across two Fugu genomic regions containing the orthologs of human genes mapping to human chromosome 20q. Contig gene contents have been assessed by sample sequencing and comparative database analyses. Contigs are centered around two Fugu topoisomerase1 (top1) genes that were initially identified by sequence similarity to human TOP1 (20q12). Two other genes (SNAI1 and KRML) mapping to human chromosome 20 are also duplicated in Fugu. The two contigs have been mapped to separate Fugu chromosomes. Our data indicate that these linkage groups result from the duplication of an ancestral chromosome segment containing at least 40 genes that now map to the long arm of human chromosome 20. Although there is considerable conservation of synteny, gene orders are not well conserved between Fugu and human, with only very short sections of two to three adjacent genes being maintained in both organisms. Comparative analyses have allowed this duplication event to be dated before the separation of Fugu and zebrafish. Our data (which are best explained by regional duplication, followed by substantial gene loss) support the hypothesis that there have been a large number of gene and regional duplications (and corresponding gene loss) in the fish lineage, possibly resulting from a single whole genome duplication event.
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