ArticleGenome research2002
Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 100 citations in OpenAlex.
- IER5 Negatively Regulates Cdc25B Expression in HeLa Cells After Gamma Ray Irradiation.BioMed research international · 2025Article
- Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.Nucleic acids research · 2020Article
- Overexpression of the immediate early response 5 gene increases the radiosensitivity of HeLa cells.Oncology letters · 2019Article
- Functional 5' UTR motif discovery with LESMoN: Local Enrichment of Sequence Motifs in biological Networks.Nucleic acids research · 2017Article
- Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq.Cell reports · 2017Article
- The hierarchical organization of natural protein interaction networks confers self-organization properties on pseudocells.BMC systems biology · 2015Article
- Identifying and mapping cell-type-specific chromatin programming of gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia.Leukemia · 2014Article
- MAP17, a ROS-dependent oncogene.Frontiers in oncology · 2012Article
- Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Developmental cell · 2011Article
- cis-Regulatory remodeling of the SCL locus during vertebrate evolution.Molecular and cellular biology · 2010Article
- Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.PloS one · 2010Article
- Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.Blood · 2009Article
- A novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity.Genome research · 2008Article
- Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis.PLoS biology · 2007Article
- WeederH: an algorithm for finding conserved regulatory motifs and regions in homologous sequences.BMC bioinformatics · 2007Article
- Real-time PCR mapping of DNaseI-hypersensitive sites using a novel ligation-mediated amplification technique.Nucleic acids research · 2007Article
- Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites.Genome research · 2006Article
- SinicView: a visualization environment for comparisons of multiple nucleotide sequence alignment tools.BMC bioinformatics · 2006Article
- Many genes in fish have species-specific asymmetric rates of molecular evolution.BMC genomics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 3 countries.
Funding
Abstract
The stem cell leukemia (SCL) gene encodes a bHLH transcription factor with a pivotal role in hematopoiesis and vasculogenesis and a pattern of expression that is highly conserved between mammals and zebrafish. Here we report the isolation and characterization of the zebrafish SCL locus together with the identification of three neighboring genes, IER5, MAP17, and MUPP1. This region spans 68 kb and comprises the longest zebrafish genomic sequence currently available for comparison with mammalian, chicken, and pufferfish sequences. Our data show conserved synteny between zebrafish and mammalian SCL and MAP17 loci, thus suggesting the likely genomic domain necessary for the conserved pattern of SCL expression. Long-range comparative sequence analysis/phylogenetic footprinting was used to identify noncoding conserved sequences representing candidate transcriptional regulatory elements. The SCL promoter/enhancer, exon 1, and the poly(A) region were highly conserved, but no homology to other known mouse SCL enhancers was detected in the zebrafish sequence. A combined homology/structure analysis of the poly(A) region predicted consistent structural features, suggesting a conserved functional role in mRNA regulation. Analysis of the SCL promoter/enhancer revealed five motifs, which were conserved from zebrafish to mammals, and each of which is essential for the appropriate pattern or level of SCL transcription.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.