ArticleJournal of neuro-oncology2002
Ki-67 labeling is correlated with the time to recurrence in primary glioblastomas.
Article in Journal of neuro-oncology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Monocentric evaluation of Ki-67 labeling index in combination with a modified RPA score as a prognostic factor for survival in IDH-wildtype glioblastoma patients treated with radiochemotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Article
- Inflammatory Tumor Microenvironment in Cranial Meningiomas: Clinical Implications and Intraindividual Reproducibility.Diagnostics (Basel, Switzerland) · 2022Article
- Correlation of post-contrast T1-weighted MRI surface regularity, tumor bulk, and necrotic volume with Ki67 and p53 in glioblastomas.Neuroradiology · 2019Article
- Evaluation of Akt and RICTOR Expression Levels in Astrocytomas of All Grades.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Long-term survival in a patient with glioblastoma on antipsychotic therapy for schizophrenia: a case report and literature review.Therapeutic advances in medical oncology · 2016Review
- Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.Oncotarget · 2016Article
- Unique spectral markers discern recurrent Glioblastoma cells from heterogeneous parent population.Scientific reports · 2016Article
- Comparison of microRNA expression levels between initial and recurrent glioblastoma specimens.Journal of neuro-oncology · 2013Article
- Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2010Article
- Role of MIB1 in predicting survival in patients with glioblastomas.Journal of neuro-oncology · 2006Article
- Prognostic value of Mdm2, p53 and p16 in patients with astrocytomas.Journal of neuro-oncology · 2004Article
- Proliferative activity of microvascular cells in glioblastomas does not correlate with time to recurrence.Journal of neuro-oncology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ki-67 labeling index (LI) was shown in many cut-off studies to be significantly correlated to the postoperative survival probability in gliomas in univariate and multivariate analyses. However, a direct relationship of the Ki-67 LI and the growth fraction, respectively, to clinical growth parameters was not demonstrated in a single tumor type of this group until now. We compared the Ki-67 LI of 20 primary glioblastomas and their recurrent tumors with the time to reoperation for recurrence. Regression analyses showed (1) a high reproducibility of the LIs at the second versus the first operation corresponding to an inherent growth potential of a given individual tumor and (2) a strong inverse correlation of LI to time to recurrence (TR) (r = -0.92). Additionally to a lower LI (corresponding to a smaller growth fraction), a longer cycle time could be derived in slowly growing as compared to rapidly growing tumors. A direct relationship of the Ki-67 LI to a clinical time parameter (the TR) was obtained, and a predictive significance of individual LIs in glioblastomas could be defined.
Indexed as
Identifiers
11995813What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.