The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.Frontiers in immunology · 2021
   Review
2. Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.Journal of immunology (Baltimore, Md. : 1950) · 2012
   Article
3. Evolution of coordinated mutagenesis and somatic hypermutation in VH5.Molecular immunology · 2011
   Article
4. Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia.Cancer research · 2010
   Article
5. AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Molecular immunology · 2008
   Article
6. Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires.Biology direct · 2006
   Article
7. DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.Annals of the New York Academy of Sciences · 2005
   Review
8. Class switching and Myc translocation: how does DNA break?Nature immunology · 2004
   Article
9. Novel antibody switching defects in human patients.The Journal of clinical investigation · 2003
   Article
10. Class-switch recombination: after the dawn of AID.Current opinion in immunology · 2003
    Review
11. Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2003
    Article

Corrections and comments

• Comment on
  DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.2002
• Comment on
  The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.2002

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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