ArticleThe Journal of experimental medicine2002
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 109 citations in OpenAlex.
- ANARCII enables alignment-free antigen receptor numbering using a generalised language model.Communications biology · 2026Article
- Insights on SNPs of Human Activation-Induced Cytidine Deaminase AID.International journal of molecular sciences · 2025Review
- HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation.Genes & development · 2022Article
- Article
- TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at theScience immunology · 2019Article
- DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.Nature methods · 2016Article
- PARP activation promotes nuclear AID accumulation in lymphoma cells.Oncotarget · 2016Article
- Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.European journal of immunology · 2014Article
- A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.Nature immunology · 2013Article
- Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences.Frontiers in immunology · 2012Article
- AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.Arthritis and rheumatism · 2011Article
- The whole-organism heavy chain B cell repertoire from Zebrafish self-organizes into distinct network features.BMC systems biology · 2011Article
- Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Molecular immunology · 2011Article
- Msh6 protects mature B cells from lymphoma by preserving genomic stability.The American journal of pathology · 2010Article
- Alternative induction of meiotic recombination from single-base lesions of DNA deaminases.Genetics · 2009Article
- Article
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2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of B cells by antigen fuels two distinct molecular modifications of immunoglobulin (Ig) genes. Class-switch recombination (CSR) replaces the Ig(mu) heavy chain constant region with a downstream constant region gene, thereby altering the effector function of the resulting antibodies. Somatic hypermutation (SHM) introduces point mutations into the variable regions of Ig genes, thereby changing the affinity of antibody for antigen. Mechanistic overlap between the two reactions has been suggested by the finding that both require the activation-induced cytidine deaminase (AID). It has been proposed that AID initiates both CSR and SHM by activating a common nuclease. Here we provide evidence that cells lacking AID, or expressing a dominant negative form of the protein, are still able to incur DNA lesions in SHM target sequences. The results indicate that an intact cytidine deaminase motif is required for AID function, and that AID acts downstream of the initial DNA lesions in SHM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.