ReviewCNS drugs2002
The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications.
Review in CNS drugs, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Meta-analysis of brain iron levels of Parkinson's disease patients determined by postmortem and MRI measurements.Scientific reports · 2016Pooled it
- Amyloid-International journal of molecular sciences · 2023Article
- Mitochondrial iron metabolism and neurodegenerative diseases.Neurotoxicology · 2022Review
- Homeostatic alterations related to total antioxidant capacity, elemental concentrations and isotopic compositions in aqueous humor of glaucoma patients.Analytical and bioanalytical chemistry · 2022Article
- Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases.International journal of molecular sciences · 2018Review
- Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study.Molecular neuropsychiatry · 2018Article
- A Peroxynitrite Dicopper Complex: Formation via Cu-NO and Cu-OJournal of the American Chemical Society · 2016Article
- Quantitative susceptibility mapping by inversion of a perturbation field model: correlation with brain iron in normal aging.IEEE transactions on medical imaging · 2015Article
- Probing the coordination environment of the human copper chaperone HAH1: characterization of Hg(II)-bridged homodimeric species in solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2013Article
- Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study.Analytical and bioanalytical chemistry · 2012Article
- Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Role of metal dyshomeostasis in Alzheimer's disease.Metallomics : integrated biometal science · 2011Review
- Iron and mechanisms of neurotoxicity.International journal of Alzheimer's disease · 2010Article
- Age-dependent and gender-specific changes in mouse tissue iron by strain.Experimental gerontology · 2009Article
- Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene.Journal of neurochemistry · 2009Article
- Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.BMC medical genomics · 2009Article
- Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.Investigative ophthalmology & visual science · 2008Article
- Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- The effect of curcumin (turmeric) on Alzheimer's disease: An overview.Annals of Indian Academy of Neurology · 2008Article
- Regional dissection and determination of loosely bound and non-heme iron in the developing mouse brain.Brain research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Abnormalities in the metabolism of the transition metals iron and copper have been demonstrated to play a crucial role in the pathogenesis of various neurodegenerative diseases. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed in this article in depth. While there is documented evidence for alterations in the homeostasis, redox-activity and localisation of transition metals, it is also important to realise that alterations in specific copper- and iron-containing metalloenzymes appear to play a crucial role in the neurodegenerative process. These changes provide the opportunity to identify pathways where modification of the disease process can occur, potentially offering opportunities for clinical intervention. As understanding of disease aetiology evolves, so do the tools with which diseases are treated. In this article, we examine not only the possible mechanism of disease but also how pharmaceuticals may intervene, from direct and indirect antioxidant therapy to strategies involving gene therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.