ArticleIrish journal of medical science
Thermolabile methylenetetrahydrofolate reductase (C677T): frequency in the Irish population.
Article in Irish journal of medical science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Distribution ofIndian journal of clinical biochemistry : IJCB · 2017Article
- Folate-related gene variants in Irish families affected by neural tube defects.Frontiers in genetics · 2013Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genetic variation which underlies the thermolability and low enzyme activity of 5,10-methylenetetrahydrofolate reductase (MTHFR; C677T) has been extensively studied in many populations, including the Irish population.
aimTo describe the examination of the C677T substitution in two new control samples drawn from the Irish population.
methodsA collection of 487 serum samples was obtained through the blood transfusion services of both the Republic of Ireland and Northern Ireland and a further 115 samples from volunteers.
resultsIn both samples, the frequency of the thermolabile/low enzyme activity allele (T) was higher than that previously reported for the Irish population.
conclusionThis finding thus supports the need for a greater use of internal control/family-based association studies, as opposed to the classic case control study design, when assessing the contribution of the MTHFR T allele to disease processes.
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