ArticleJournal of virology2002
Characterizing and mapping porcine endogenous retroviruses in Westran pigs.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Determination of the Copy Number of Porcine Endogenous Retroviruses (PERV) in Auckland Island Pigs Repeatedly Used for Clinical Xenotransplantation and Elimination of PERV-C.Microorganisms · 2024Article
- Scan of the endogenous retrovirus sequences across the swine genome and survey of their copy number variation and sequence diversity among various Chinese and Western pig breeds.Zoological research · 2022Article
- Screening pigs for xenotransplantation in China: investigation of porcine endogenous retrovirus in Diannan small-eared pigs.Virus genes · 2020Article
- PERVading strategies and infectious risk for clinical xenotransplantation.Xenotransplantation · 2018Review
- Genetically Modified Pigs as Organ Donors for Xenotransplantation.Molecular biotechnology · 2017Review
- A high-quality annotated transcriptome of swine peripheral blood.BMC genomics · 2017Article
- How Active Are Porcine Endogenous Retroviruses (PERVs)?Viruses · 2016Review
- Review
- Characterization of insertional variation of porcine endogenous retroviruses in six different pig breeds.Asian-Australasian journal of animal sciences · 2012Article
- Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.Clinical microbiology reviews · 2012Review
- Characterization of porcine endogenous retrovirus clones from the NIH miniature pig BAC library.Journal of biomedicine & biotechnology · 2012Article
- Suboptimal porcine endogenous retrovirus infection in non-human primate cells: implication for preclinical xenotransplantation.PloS one · 2010Article
- Reliable classification and recombination analysis of porcine endogenous retroviruses.Virus genes · 2005Article
- Porcine endogenous retroviruses infect cells lacking cognate receptors by an alternative pathway: implications for retrovirus evolution and xenotransplantation.Journal of virology · 2004Article
- Genotyping of porcine endogenous retroviruses from a family of miniature swine.Journal of virology · 2004Article
- Relative age of proviral porcine endogenous retrovirus sequences in Sus scrofa based on the molecular clock hypothesis.Journal of virology · 2003Article
- Characterization of endogenous retroviruses in sheep.Journal of virology · 2003Article
- Characterization of two porcine endogenous retrovirus integration loci and variability in pigs.Immunogenetics · 2003Article
- Characterization of porcine endogenous retrovirus gamma pro-pol nucleotide sequences.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since porcine endogenous retroviruses (PERVs) can infect cultured human cells, they are a potential hazard to xenotransplantation. For this reason, endogenous retroviruses from the Westran (Westmead Hospital transplantation) inbred line of pigs were analyzed by using consensus primers for the type A and type B viruses to amplify 1.8-kb envelope gene fragments. After preliminary analysis with restriction enzymes KpnI and MboI, 31 clones were sequenced. Between types A and B, five recombinant clones were identified. Fifty-five percent of clones (17 of 31) had premature stop codons within the envelope protein-encoding region. Endogenous retroviruses in Westran pigs were physically mapped by fluorescence in situ hybridization (FISH) using PERV-A and PERV-B envelope clones as probes to identify at least 32 integration sites (19 PERV-A sites and 13 PERV-B sites). The chromosomal sites of integration in the Westran strain are quite different from those in the European Large White pig. The recombinant clones suggest that defective PERVs could become infective through recombination and further that PERVs might recombine with human endogenous retroviruses in xenotransplants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.