ArticleDigestive diseases and sciences2002
p73 overexpression and nuclear accumulation in hepatitis C virus-associated hepatocellular carcinoma.
Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients.Bioscience reports · 2019Article
- Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma.Journal of translational medicine · 2019Article
- Chemoprevention of hepatocellular carcinoma in patients with hepatitis C virus related cirrhosis.World journal of hepatology · 2013Review
- Tumor suppressor and hepatocellular carcinoma.World journal of gastroenterology · 2008Review
- Expression and clinical significance of TAp73alpha, p53, PCNA and apoptosis in hepatocellular carcinoma.World journal of gastroenterology · 2005Article
- Physical and functional interaction between HCV core protein and the different p73 isoforms.Oncogene · 2003Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p73 is the first identified homolog of p53, but its function has not been established. Our study investigated the expression of p73 in liver tissue of patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC). RT-PCR was performed on RNA extracted from tumorous and nontumorous liver tissue of HCV-associated HCC, and control tissue and the cDNA were sequenced. Anti-p73 polyclonal antibodies were used for protein analysis and immunohistochemistry, and patients' sera were analyzed for anti-p73 antibodies by radioimmunoassay. Analysis of the p53 gene was performed by SSCP and RFLP-PCR. The p73 mRNA and protein were highly expressed and accumulated in HCC tissues. Immunohistochemical studies revealed significant immunoreactivity in the nuclei of HCC cells. No mutations were detected in the p73 gene or in p53, and no loss of heterozygosity of the p53 gene was found. Anti-p73 antibodies were detected in sera of HCC patients, but were not significantly different from that occurring in non-HCV or non-HCC patients. In conclusion, p73 protein is overexpressed and accumulates in the nuclei of HCV-associated HCCs and may play a role in HCC development.
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Registered trials
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