ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2002
Blood and milk cellular immune responses of mastitic non-periparturient cows inoculated with Staphylococcus aureus.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Standardized Whole Blood Assay and Bead-Based Cytokine Profiling Reveal Commonalities and Diversity of the Response to Bacteria and TLR Ligands in Cattle.Frontiers in immunology · 2022Article
- Sensitive and rapid lateral-flow assay for early detection of subclinical mammary infection in dairy cows.Scientific reports · 2020Article
- Identification of Gene Modules and Hub Genes Involved in Mastitis Development Using a Systems Biology Approach.Frontiers in genetics · 2020Article
- Effect of intramammary infusion of recombinant bovine GM-CSF and IL-8 on CMT score, somatic cell count, and milk mononuclear cell populations in Holstein cows with Staphylococcus aureus subclinical mastitis.Veterinary research communications · 2017Article
- Effect of intramammary infusion of rbGM-CSF on SCC and expression of polymorphonuclear neutrophil adhesion molecules in subclinical mastitis cows.Veterinary research communications · 2012Article
- Decrease in bovine CD14 positive cells in colostrum is associated with the incidence of mastitis after calving.Veterinary research communications · 2010Article
- Proof of concept of a method that assesses the spread of microbial infections with spatially explicit and non-spatially explicit data.International journal of health geographics · 2008Article
- Multifactorial relationships between intramammary invasion by Staphylococcus aureus and bovine leukocyte markers.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphocyte function and phenotype of peripheral blood and mammary gland cells were evaluated in non-periparturient cows before and at 1, 4 to 8 and 9 to 14 d after inoculation with Staphylococcus aureus, as expressed by percentage of CD3+, CD2+, and CD45R+ cells, antigen density of these markers per lymphocyte, and mitogen-induced blastogenesis. Milk bacterial counts and somatic cell counts (SCC) were also assessed. Mitogen-induced blastogenic responses were strong in blood and weak in mammary gland cells in all observations and positively correlated with the percent of CD45R+ cells. Significantly greater percentages of milk CD3+ lymphocytes and increased CD3, CD2, and CD45R antigen density per cell were observed after challenge. The blood CD3 and CD2 antigen density per lymphocyte and the milk CD2+ lymphocyte percent were negatively correlated with SCC (P < or = 0.01). No mastitis (SCC < or = 500 000 cells/mL) was observed in cows showing blood lymphocyte CD2 and CD3 antigen density indices < or = 2.5 and 6, respectively. Forty-one percent of SCC values were predicted by the combined blood CD2 and milk CD3 antigen density (P < or = 0.01). These findings support the hypotheses that mitogen-induced lymphocyte blastogenesis is not a valid test to assess mammary gland immunocompetence and that CD2 expression may facilitate immune responses by decreasing the number of T cell receptors required to achieve full activation.
Indexed as
Identifiers
11989735PMC226995W31842557What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.