ArticleMolecular psychiatry2002
Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.
Article in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Glutamatergic abnormalities of the thalamus in schizophrenia: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2008Pooled it
- Structural insights into kainate receptor desensitization.Nature communications · 2025Article
- Structural basis of GluK2 kainate receptor activation by a partial agonist.Nature structural & molecular biology · 2025Article
- Ultrarare Loss-of-Function Mutations in the Genes Encoding the Ionotropic Glutamate Receptors of Kainate Subtypes Associated with Schizophrenia Disrupt the Interaction with PSD95.Journal of personalized medicine · 2022Article
- Structure, Function, and Regulation of the Kainate Receptor.Sub-cellular biochemistry · 2022Review
- A Neural "Tuning Curve" for Multisensory Experience and Cognitive-Perceptual Schizotypy.Schizophrenia bulletin · 2017Article
- Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.Cell reports · 2017Article
- Article
- Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.Molecular pharmacology · 2015Review
- Heritability and molecular genetic basis of acoustic startle eye blink and affectively modulated startle response: a genome-wide association study.Psychophysiology · 2014Article
- Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia.Biomedical reports · 2014Article
- Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.Brain research · 2012Article
- Glutamate neurocircuitry: theoretical underpinnings in schizophrenia.Frontiers in pharmacology · 2012Article
- Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.Handbook of experimental pharmacology · 2012Review
- Physiology and pathology of calcium signaling in the brain.Frontiers in pharmacology · 2012Article
- Therapeutic potential of kainate receptors.CNS neuroscience & therapeutics · 2011Review
- Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.BMC psychiatry · 2004Article
- Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice.Neurotoxicity research · 2004Article
- Linkage and association studies of schizophrenia.Current psychiatry reports · 2003Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a severe psychiatric illness characterised by disturbance of thought, hallucination and delusions.(1) Several studies have suggested that dysfunctions in the glutamatergic transmission are linked to the pathogenesis of schizophrenia, and in particular an excessive activation of glutamate receptors seems to be related to the disruption of neuronal ionic gradients leading to excitotoxicity.(2-7) Numerous findings suggested that the kainate ionotropic glutamate receptors are primarily involved in this mechanism. Recently it has been demonstrated that the GRIK3 gene encoding for the ionotropic glutamate receptor kainate 3 contains a functional polymorphism (T928G) leading to the substitution of a serine with an alanine in position 310 of the protein sequence.(8-11) We performed an association study between the ser310ala GRIK3polymorphism and schizophrenia in a sample of 99 schizophrenic patients and 116 controls. We found a significant difference in the genotype distribution and in particular considering the ala allele as dominant (P = 0.0105, odds ratio (OR) 2.031, 95% confidence interval (CI) 1.177-3.504). This finding suggests a potential role for GRIK3 for susceptibility to schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.