Evidence map›Paper›PMID 11986984›Full record

SynthesisMolecular psychiatry2002

Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.

J A Badner, E S Gershon

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 269 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

269 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Trial
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  12. Review
  13. Article
  14. Article
  15. The 14-3-3 Protein Family and Schizophrenia.Frontiers in molecular neuroscience · 2022
    Review
  16. Review
  17. Article
  18. Genetics of schizophrenia (Review).Experimental and therapeutic medicine · 2020
    Review
  19. Review
  20. Article

209 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J A BadnerDepartment of Psychiatry, University of Chicago, Chicago, IL 60637, USA. jbadner@yoda.bsd.uchicago.edu
E S Gershon

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Badner and Gershon (2001) presented a technique of meta-analysis of linkage data that could be applied to published genome scans. It combines the reported P-values of individual studies, after correcting each value for the size of the region containing a minimum P-value. Simulations demonstrated that the type I error rate was at least as low as that for a single genome scan and thus genome-wide significance criteria may be applied. Power to detect linkage was at least as high as the power of pooling the data from all the studies. We applied this method to all the published genome scans for bipolar disorder and schizophrenia. We found the strongest evidence for susceptibility loci on 13q (P < 6 x 10(-6)) and 22q (P < 1 x 10(-5)) for bipolar disorder, and on 8p (P < 2 x 10(-4)), 13q (P < 7 x 10(-5)), and 22q (P < 9 x 10(-5)) for schizophrenia.

Indexed as

Genetic LinkageGenome, HumanBipolar DisorderGenetic Predisposition to DiseaseHumansSchizophrenia

Identifiers

PMID11986984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.