ReviewMolecular psychiatry2002
Manic-depression genes and the new millennium: poised for discovery.
Review in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of 12 genomic studies in bipolar disorder.Journal of molecular neuroscience : MN · 2007Pooled it
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- Influencing factors for mental health of general practitioners in Hebei Province under the outbreak of COVID-19: A cross-sectional study.International journal of clinical practice · 2021Article
- A balanced translocation disrupting BCL2L10 and PNLDC1 segregates with affective psychosis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population.Iranian Red Crescent medical journal · 2015Article
- A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis.BioData mining · 2015Article
- Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome.The application of clinical genetics · 2014Review
- Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- An investigation of candidate regions for association with bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization.The Psychiatric clinics of North America · 2010Review
- A genome screen of 35 bipolar affective disorder pedigrees provides significant evidence for a susceptibility locus on chromosome 15q25-26.Molecular psychiatry · 2009Article
- Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population.Journal of psychiatry & neuroscience : JPN · 2009Article
- The expression of folate sensitive fragile sites in patients with bipolar disorder.Yonsei medical journal · 2009Article
- Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese.Behavioral and brain functions : BBF · 2008Article
- Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder.Molecular psychiatry · 2006Article
- Psychosis and the genetic spectrum of bipolar disorder: evidence from linkage analysis.Molecular psychiatry · 2006Article
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.American journal of human genetics · 2005Article
- Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4.Molecular psychiatry · 2005Article
- Absence of psychosis may influence linkage results for bipolar disorder.Molecular psychiatry · 2005Article
- Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population.American journal of human genetics · 2005Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Manic-depressive illness is a common psychiatric disorder with complex etiology that likely involves multiple genes and non-genetic influences. The uncertain path to gene discovery has spurred considerable debate over genetic findings and gene-finding strategies. In this article, I review the main findings, with a focus on: (1) putative linked loci on chromosomes 1q31-32, 4p16, 6pter-p24, 10p14, 10q21-26, 12q23-24, 13q31-32, 18p11, 18q21-23, 21q22, 22q11-13, and Xq24-28; and (2) association studies with candidate genes, dynamic mutations, mitochondrial mutations, and chromosomal aberrations. Although no gene has been identified, promising findings are emerging. I then discuss the challenges and opportunities ahead, with special emphasis on gene-finding methods-in particular, questions pertaining to phenotype definition, linkage and association mapping, gene markers, sampling, study population, multigene systems, lessons from other disorders, animal models, and bioinformatics. The progress to date, together with rapid advances in genomics, analytical and computational methods, and bioinformatics, holds promise for new insights into the genetics of manic-depression, in the new millennium.
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