ArticleThe Journal of physiology2002
Mechanical function of intermediate filaments in arteries of different size examined using desmin deficient mice.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- What does desmin do: A bibliometric assessment of the functions of the muscle intermediate filament.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Mechanical programming of arterial smooth muscle cells in health and ageing.Biophysical reviews · 2021Review
- Vascular smooth muscle contraction in hypertension.Cardiovascular research · 2018Review
- Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice.Scientific reports · 2017Article
- The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function.Anatomical record (Hoboken, N.J. : 2007) · 2014Review
- Intermediate filaments in smooth muscle.American journal of physiology. Cell physiology · 2008Review
- Role of vimentin in smooth muscle force development.American journal of physiology. Cell physiology · 2006Article
- Desmin filaments influence myofilament spacing and lateral compliance of slow skeletal muscle fibers.Biophysical journal · 2005Article
- Desmin ensheathment ratio as an indicator of vessel stability: evidence in normal development and in retinopathy of prematurity.The American journal of pathology · 2004Article
- Nonmuscle Myosin motor of smooth muscle.The Journal of general physiology · 2003Article
- Decreased shortening velocity and altered myosin isoforms in guinea-pig hypertrophic intestinal smooth muscle.The Journal of physiology · 2002Article
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Authors and funding
5 authors.
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Abstract
Protein composition and mechanical function of intermediate filaments were examined in arteries of different sizes using desmin deficient mice (Des-/-) and their wild-type controls (Des+/+). Using SDS-PAGE gels and Western blots we found a gradient in desmin expression in the arterial tree; the desmin content increased from the elastic artery aorta, via the muscular mesenteric artery to the resistance-sized mesenteric microarteries approximately 150 microm in diameter in Des+/+ mice. Mechanical experiments were performed on the aorta, the mesenteric artery and resistance-sized arteries using wire myographs. For aorta and mesenteric artery, no differences in passive or active circumference- stress relations were found between Des-/- and Des+/+ mice. In microarteries, both passive and active stress were lower in the Des-/- group. In conclusion, large elastic and muscular arteries contain a relatively low amount of desmin, and the desmin intermediate filaments do not seem to play a major role in the mechanical properties of these larger arterial vessels. In the microarteries, where expression of desmin is high, desmin plays a role in supporting both passive and active tension.
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