ArticleThe Journal of physiology2002
Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 70 citations in OpenAlex.
- Modulating CaBiophysical journal · 2024Article
- Fast inactivation of Nav1.3 channels by FGF14 proteins: An unconventional way to regulate the slow firing of adrenal chromaffin cells.The Journal of general physiology · 2021Article
- A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ.The Journal of physiology · 2021Article
- Kv7 Channels and Excitability Disorders.Handbook of experimental pharmacology · 2021Article
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- Distinct patterns of exocytosis elicited by CaPflugers Archiv : European journal of physiology · 2018Article
- Roles of NaPflugers Archiv : European journal of physiology · 2018Review
- Muscarinic receptors in adrenal chromaffin cells: physiological role and regulation of ion channels.Pflugers Archiv : European journal of physiology · 2018Review
- Low pHThe Journal of physiology · 2017Article
- Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues.Molecular and cellular neurosciences · 2015Article
- Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells.The Journal of physiology · 2015Article
- Cav1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells.Current molecular pharmacology · 2015Review
- Adrenal adrenoceptors in heart failure.Frontiers in physiology · 2014Review
- Nerve growth factor-induced endocytosis of TWIK-related acid-sensitive K⁺ 1 channels in adrenal medullary cells and PC12 cells.Pflugers Archiv : European journal of physiology · 2013Article
- Mechanisms and roles of muscarinic activation in guinea-pig adrenal medullary cells.American journal of physiology. Cell physiology · 2012Article
- Contribution of BK channels to action potential repolarisation at minimal cytosolic Ca2+ concentration in chromaffin cells.Pflugers Archiv : European journal of physiology · 2011Article
- Ca(v)1.3 and BK channels for timing and regulating cell firing.Molecular neurobiology · 2010Review
- Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- PDE type-4 inhibition increases L-type Ca(2+) currents, action potential firing, and quantal size of exocytosis in mouse chromaffin cells.Pflugers Archiv : European journal of physiology · 2009Article
- Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells.Archives of biochemistry and biophysics · 2008Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study has investigated the electrophysiological responses evoked by histamine in bovine adrenal chromaffin cells using perforated-patch techniques. Histamine caused a transient hyperpolarization followed by a sustained depolarization of 7.2 +/- 1.4 mV associated with an increase in spontaneous action potential frequency. The hyperpolarization was abolished after depleting intracellular Ca(2+) stores with thapsigargin (100 nM), and was reduced by 40 % with apamin (100 nM). Membrane resistance increased by about 60 % during the histamine-induced depolarization suggesting inhibition of a K(+) channel. An inward current relaxation, typical of an M-current, was observed in response to negative voltage steps from a holding potential of -30 mV. This current reversed at -81.6 +/- 1.8 mV and was abolished by the M-channel inhibitor linopirdine (100 microM). During application of histamine, the amplitude of M-currents recorded at a time corresponding with the sustained depolarization was reduced by 40 %. No inward current rectification was observed in the range -150 to -70 mV, and glibenclamide (10 microM) had no effect on either resting membrane potential or the response to histamine. The results show that an M-current is present in bovine chromaffin cells and that this current is inhibited during sustained application of histamine, resulting in membrane depolarization and increased discharge of action potentials. These results demonstrate for the first time a possible mechanism coupling histamine receptors to activation of voltage-operated Ca(2+) channels in these cells.
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