ArticleJournal of clinical pathology2002
Pancreatic cancer after remote peptic ulcer surgery.
Article in Journal of clinical pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Pancreatic cancer mimicking ectopic pancreas origin: a rare case after neonatal pyloromyotomy.Clinical journal of gastroenterology · 2026Article
- A Risk Analysis for Ischemic Necrosis of the Remnant Stomach After Distal Pancreatectomy in Patients With Previous Distal Gastrectomy: A Multicenter Retrospective Survey by the Japanese Society of Pancreatic Surgery.Journal of hepato-biliary-pancreatic sciences · 2025Article
- Safety of performing distal pancreatosplenectomy in patients who underwent distal gastrectomy previously: a multicenter cohort analysis with systematic literature review.Annals of surgical treatment and research · 2022Article
- Cancer incidence in Spain, 2015.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- Intraoperative assessment of tissue oxygen saturation of the remnant stomach by near-infrared spectroscopy in two cases of pancreatectomy following gastrectomy.International journal of surgery case reports · 2016Article
- Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- Is preservation of the remnant stomach safe during distal pancreatectomy in patients who have undergone distal gastrectomy?World journal of surgery · 2013Article
- Proton pump inhibitors and histamine-2-receptor antagonists and pancreatic cancer risk: a nested case-control study.British journal of cancer · 2012Article
- Pancreatic neuroma-like lesions after upper abdominal surgery: a clinicopathological postmortem study.Virchows Archiv : an international journal of pathology · 2010Article
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Authors and funding
9 authors.
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Abstract
backgroundPeptic ulcer surgery may carry an increased risk for pancreatic cancer development. Molecular analysis of K-ras codon 12, frequently mutated in conventional pancreatic cancers, might provide insight into the aetiological mechanisms.
methodsThe relative risk of pancreatic cancer was computed by multivariate and person-year analysis in a cohort of 2633 patients who had undergone gastrectomy. Lung cancer risk was analysed as an indirect means of assessing smoking behaviour. K-ras codon 12 mutational analysis was performed on 15 postgastrectomy pancreatic cancers.
resultsThere was an overall increased risk of pancreatic carcinoma of 1.8 (95% confidence interval, 1.3 to 2.6) five to 59 years postoperatively, which gradually increased to 3.6 at 35 years or more after surgery (chi(2) test for trend, p < 0.05). Multivariate analysis indicated that parameters other than postoperative interval did not influence the risk. Lung cancer risk was significantly increased after surgery, but no time trend was observed. The spectrum and prevalence of K-ras codon 12 mutations were comparable to conventional pancreatic cancer.
conclusionsRemote partial gastrectomy is associated with an increased risk of pancreatic cancer. Postgastrectomy and non-postgastrectomy pancreatic cancers may share similar aetiological factors, such as smoking. However, the neoplastic process in patients who have undergone gastrectomy appears to be accelerated by factors related to the surgery itself.
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