ArticleJapanese journal of cancer research : Gann2002
Association of HLA-DQB1*0301 and HLA-DQB1*0602 with different subtypes of gastric cancer in Taiwan.
Article in Japanese journal of cancer research : Gann, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Specific HLA-DQB1 alleles associated with risk for development of hepatocellular carcinoma: a meta-analysis.World journal of gastroenterology · 2011Pooled it
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- Genomic analyses identify 15 risk loci and revealProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome.Journal of personalized medicine · 2024Article
- Association between human leukocyte antigen gene polymorphisms and multiple EPIYA-C repeats in gastrointestinal disorders.World journal of gastroenterology · 2020Article
- A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck.Cancer research · 2020Article
- Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- HLA-DQB1*03 genotype and perioperative blood transfusion are not conducive to the prognosis of patients with gastric cancer.Journal of clinical laboratory analysis · 2018Article
- Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium.Carcinogenesis · 2016Article
- Article
- HLA Class I Allele Frequencies in Southern Iranian Women with Breast Cancer.Iranian journal of basic medical sciences · 2013Article
- HLA class-II allele frequencies in Turkish breast cancer patients.Medical oncology (Northwood, London, England) · 2012Article
- Association between HLA-DQB1 gene and patients with acute lymphoblastic leukemia (ALL).International journal of hematology · 2012Article
- Distribution of HLA Tissue Groups in Patients with Gastric Cancer.The Eurasian journal of medicine · 2010Article
- Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients.World journal of gastroenterology · 2006Article
- HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia?Pathology oncology research : POR · 2006Article
- HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer in a high risk population, China.Immunogenetics · 2005Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer (GC) is a heterogeneous disorder with multifactorial etiologies. Genetic predisposition, environmental factors, and Helicobacter pylori infection are thought to interact in the manifestation of GC. Particular human leukocyte antigen (HLA) alleles play a pivotal role in cellular immunity and may be an important genetically determined host trait. To elucidate the association between the genotype of HLA class II genes and the clinical phenotype of GC, polymorphisms of HLA-DRB1 and HLA-DQB1 were determined by polymerase chain reaction with sequence-specific primers in 106 Taiwanese patients with GC and in 208 healthy controls. Comparison of allele frequencies between GC patients and healthy controls showed no significant difference at the HLA-DRB1 locus. Patients with GC had a higher frequency of DQB1(*)0602 (9.4% vs. 3.6%, P < 0.05, odds ratio 2.79, 95% confidence interval 1.41 - 5.47) and a lower frequency of DQB1(*)0301 (14.6% vs. 23.8%, P < 0.05, odds ratio 0.55, 95% confidence interval 0.35 - 0.85) compared to healthy controls. Correlation of HLA-DQB1 status with clinicopathologic features revealed predominance of male gender (16/3 vs. 50/37, P < 0.05) and proximal location (12/7 vs. 28/59, P < 0.05) in patients with positive HLA-DBQ1(*)0602 compared to those with negative HLA-DBQ1(*)0602. In contrast, a higher ratio of diffuse/intestinal subtype (20/10 vs. 30/46, P < 0.05) and a lower seropositivity of Helicobacter pylori (14/30 vs. 58/76, P < 0.005) were noted in patients with positive HLA-DQB1(*)0301 compared to those with negative HLA-DQB1(*)0301. In conclusion, HLA-DQB1(*)0602 confers susceptibility to gastric cancer, especially for male Taiwanese and proximal tumor location, while HLA-DQB1(*)0301 may have a protective effect on GC, probably through resistance to Helicobacter pylori infection. HLA-DQB1 alleles are associated with susceptibility or resistance to GC and also influence its clinical features.
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